生物药剂学与药物动力学-第十章-重复给药课件.ppt

1、第十章第十章 重复给药重复给药江苏大学药学院药剂系江苏大学药学院药剂系 戈延茹戈延茹ssCminssCmaxktknkneeeVXC1100.nken当ktkeeVXCss)11(0)11(.00maxksseVXCt 时当kksseeVXCt)11(.0min时当kkksssseeVXeVXCC)11()11(00minmaxVXeeVXCCkkssss00minmax)1)(11(VXCCssss0minmaxnkktkktknkssnnsseeeVXeeeVXCCf1)11()11(00)(nknssef1)(kt/693.02/12/1/693.0)(1tnnssef2/1/693.0

2、)(1tnnssef整理，得：2/1)(303.2693.0)1lg(tnfnss两边取对数：)1lg(32.3)(2/1nssftnkktktksseeCeeCCCR11)11(001倍。第一次给药浓度的间隔给药时，坪浓度是意义：按R)1111()(0tkknkktknkaanaaaeeeeeekkVFXkC稳态血药浓度.20.0.anknkeen当)1111()(0tkkktkaaaaeeeekkVFXkCss)1()1(log303.2maxakkaekekkkat得，求时，当maxmax0tdtdCttss)11()(maxmax0maxaaktkkktaasseeeekkVFXkC)

3、1(max0maxkktsseeVFXC)11()(0minaakkkkaasseeeekkVFXkC)1)(1()1()1(11aaaaakkkkkkkkkkeeeeeeeeee)1)(1(11)1)(1(aaaakkkkkkkkeeeeeeee)1111()(0minakkaasseekkVFXkC0.akaekk当)1(0minkksseeVFXCkkkeekfanknkanssa1)()1)(1(1minminakksseeCCRssC0dtCCssss000001)11()11(ktkktkssekeVXdteeVXdtCkCVkXkekeVXkk0000)1()1(kCdtCAUC

4、00单室模型：VkXdtCCssss00ssC波动情况。了之间的一个浓度体现不与是在ssssssssCCCCminmax00CdtdtCssVkXdtCCssss000dtCCssssdteeeekkVFXkdtCaaktkkktaass)11()(0001111)(000dteedteekkVFXktkkktkaaaa)1()1()(000dteedteekkVFXkaaktkkktaa)1(11)1(11)(000tkakktkaaaaekeekekkVFXkVkFXkkkkVFXkaaa0011)(ssCVkX0静脉注射也可用%100)1(%100maxminmaxksssssseCCC

5、FIkCCCDFssssssminmax%100)1(%100minminmaxkksssssseeCCC血药浓度变化率表示负荷剂量用0X keVXC01ssCCmin1kkkeeVXeVX)1(00keXX100keR1100XRX2/12/1693.0001tteXX693.0001eXX002 XX)()(01akkaaeekkVFXkC)11()(0minaakkkkaasseeeekkVFXkCssCCmin1若)11()(00aaakkkkkkeeeeXeeX)1)(1()()(00aaakkkkkkeeeeXeeX)1)(1(00akkeeXXkeXX100002/12.XXt若3435ksssseCCmaxminssssCCkminmaxln1kt693.02/1ssssCCtminmax2/1ln44.136VkFXdtCCssss00ssCVkFX0ssCVkX0静脉注射也可用37