临床医学文献检索阅读评价和应用课件.ppt

1、临床医学文献检索、阅读、评价与应用 检索途径题录型数据库中国生物医学文献数据库（CBM）Medline全文型数据库中文科技期刊数据库（VIP）万方数据知识平台中国知网（CNKI）Medline检索保存和跟踪检索结果获取全文的途径其他途径中国科学院上海生命科学研究院复旦大学上海医学院上海图书馆交通大学Google 题目英文关键词 filetype:PDF联系作者论坛代理重要工具华东地区西文生物医学期刊馆藏联合目录各家图书馆订阅的外文期刊纸质版复旦大学医科图书馆有电子检索阅读的目的了解临床证据-Cochrane Library，Clinical Evidence，高IF SCI论文最新进展Pubm

2、ed-Abstract研究方法Methods讲演、兴趣-精读了解背景-Introduction相互比较-Discussion评价质量-Methods文章的结构Title and running titleTitle and running titleAuthors and addressesAuthors and addressesAbstractAbstractKeywords and abbreviationsKeywords and abbreviationsIntroductionIntroductionMaterials and methodsMaterials and method

3、sResultsResultsDiscussionDiscussionAcknowledgmentsAcknowledgmentsReferencesReferencesTables and figuresTables and figures TitleTitle Abstract Abstract Figures Figures Tables Tables Results and discussion Results and discussion Rest of the paper Rest of the paper影响因子（Impact Factor）发表文章篇数：2009=597，201

4、9=577；合计=11742019年引用次数：2009=4341，2019=4122；合计=8463IF=8463/1174=7.2092019年6月中下旬公布文章质量评价Jadad评分Cochrane HandbookCochrane Back Review GroupCONSORT声明Jadad 评分随机分组序列的产生方法 2分：计算机或随机数字表1分：提到随机，但未详细说明0分：半随机或未随机双盲2分：描述了实施双盲的具体方法并且被认为是恰当的，如采用完全一致的安慰剂等1分：试验仅提及采用双盲法0分：试验提及采用双盲，但方法不恰当，如比较片剂与注射剂而未提及使用双伪法退出与失访1分：详细

5、说明了退出与失访的理由0分：没有提及Cochrane Back Review GroupFurlan AD,Pennick V,Bombardier C,van Tulder M,the Editorial Board of the Cochrane Back Review Group.2009 Updated method guidelines for systematic reviews in the Cochrane Back Review Group.Spine 2009;34(18):192941.CONSORT清单详细内容引言Broad information on topicPr

6、evious researchNarrower background informationNeed for studyFocus of paperHypothesis and PurposeSurgery is the treatment of choice for patients with disease stage I and II non-small cell lung cancer(NSCLC)An NSCLC meta-analysis combined the results from eight randomised trials of surgery versus surg

7、ery plus adjuvant cisplatin-based chemotherapy and showed a small,but not significant(p=0.08),absolute survival benefit of around 5%at 5 years(from 50%to 55%).At the time the current trial was designed(mid-1990s),adjuvant chemotherapy had not become standard clinical practice The clinical rationale

8、for neo-adjuvant chemotherapy is three-fold:regression of the primary cancer could be achieved thereby facilitating and simplifying or reducing subsequent surgery;undetected micro-metastases could be dealt with at the start of treatment;and there might be inhibition of the putative stimulus to resid

9、ual cancer by growth factors released by surgery and by subsequent wound healing The current trial was therefore set up to compare,in patients with resectable NSCLC,surgery alone versus three cycles of platinum-based chemotherapy followed by surgery in terms of overall survival,quality of life,patho

10、logical staging,resectability rates,extent of surgery,and time to and site of relapse.CONSORT清单详细内容CONSORT清单详细内容（续一）CONSORT清单详细内容（续二）CONSORT清单详细内容（End）CONSORT Group.CONSORT 2019 Statement:Updated Guidelines for Reporting Parallel Group Randomized Trials.Ann Intern Med.2019;152.David Moher,et al.CONS

11、ORT 2019 Explanation and Elaboration:updated guidelines for reporting parallel group randomised trials.BMJ 2019;340:c869评价对象例数评价对象例数n n=排除例数排除例数n n=例，例，不符合不符合 例，拒绝参例，拒绝参与与 例，其它原因例，其它原因 例。例。随机分组例数随机分组例数n n=分配至实验组例数分配至实验组例数n n=接受分配接受分配 例例,不接受分配不接受分配 例例分配至对照组例数分配至对照组例数n n=接受分配接受分配 例例,不接受分配不接受分配 例例失访例数失

12、访例数n n=未依从计划未依从计划 例例失访例数失访例数n n=未依从计划未依从计划 例例纳入分析例数纳入分析例数n n=排除分析例数排除分析例数n n=纳入分析例数纳入分析例数n n=排除分析例数排除分析例数n n=CONSORTCONSORT流程图流程图好文章的要求（4C）Clear：思路清晰、逻辑性强、概念清楚、层次 清楚、表达清楚、语句通顺Complete：内容完整、结构完整，忌虎头蛇尾Correct：内容正确，数据数据正确、可信，文法正确Concise：论述深刻、充分揭示其文章内涵文章实例Oseltamivir Compared With the Chinese Traditional Therapy Maxingshigan Yinqiaosan in the Treatment of H1N1 InfluenzaAnn Intern MedIF：16.729