星形细胞瘤基础医学医药卫生专业资料课件.ppt

1、Lecturer:Guo Xiang Classification and Diagnosis of astrocytoma(星形细胞瘤星形细胞瘤)Morbidity of AstrocytomaAstrocytic tumor78%Glioma Primary brain tumor 40%MorbidityType of AstrocytomaWHO classification级级 毛细胞型星形细毛细胞型星形细胞瘤、室管膜下胞瘤、室管膜下巨细胞星形细胞巨细胞星形细胞瘤瘤级级弥漫型星形细胞瘤弥漫型星形细胞瘤级级间变型间变型星形细星形细胞瘤胞瘤级级胶质母细胞瘤胶质母细胞瘤Pilocytic

2、astrocytoma AND Subependymal giant cell astrocytomas Diffuse astrocytoma Anaplastic astrocytoma Glioblastoma Subependymal giant cell astrocytomas-Grade Reddish-yellow pimples chromosomal disorder染色体疾病染色体疾病n epiloia（结节性硬化）（结节性硬化）n 8Y18Y(male-to-female ratio=3:1)n subependymal nodulesn contrast-enhanc

3、en hydrocephalus脑积水脑积水n favorable clinical outcome红黄色丘疹T1T2T1-enhanceCT non-contrastM 16yPilocytic astrocytoma-Grade ChildrenCerebellum hemispheres or vermisSolid and cystic partNormal tissuesolid nodulecystic massCSF in density on NCCTMRI:a high-signal-intensity cyst surrounding a iso-intensity mur

4、al nodule on T2Contrast enhancement with both CT and MRIvermisF 62Y T1T2T1-enhancePathology弥漫型星形细胞瘤属于交界性肿瘤，容易复发，且恶性度有不断增加的趋势，最终发展为胶质母细胞瘤。Grade-Diffuse astrocytoma Grade-Anaplastic astrocytomaGrade-Glioblastoma Diffuse astrocytoma-Grade borderline tumor surgerymalignancy will be higherrecurImaging Ch

5、aracteristic Brainstem or supratentorial white matter poorly defined border Low-density on CT slightlyCSF No significant enhancementnNo or slightly enhancementCystic changeT1WI hypointensity signal T2WI hyperintensity signalF 54YSurgical field and Specimen The tumor showed diffusely infiltrated grow

6、ing.NO hemorrhage and necrosis.Anaplastic astrocytoma-Gradethe tumor enhanced distinctlyT1-enhanceFLAIRT1T2T1Glioblastoma-Grade-Adulthood Mixed density or signal lesion Hemorrhage and necrosis Contrast-enhance Because the treatment of astrocytoma is mainly based on pathological type,so it will be very helpful to make an accurate diagnosis to the level of cells.