抗高血压药-整理英文版课件.ppt
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1、 Antihypertensive drugshypertensionMean arterial blood pressure is higher than the normal range,in the case of not taking blood pressure drugs:Systolic blood pressure 18.7kPa(140mmHg)and(or)Diastolic blood pressure 12.0kPa(90mmHg)Divided into primary hypertension(90%95%)And secondary hypertension co
2、mplicationsHeart failureCoronary heart disease(CHD)Cerebrovascular accidentRenal failureAntihypertensive drugsReasonable application of antihypertensive drugsControl of blood pressureDelay the formation and development of atherosclerosisReduce the complications such as brain,heart and kidneyReduce t
3、he mortality rate,prolong lifeBlood pressure -The factors influencing blood pressure:Cardiac output:heart rate,myocardial contraction force,change of blood volume,etc.;Peripheral resistance:the length of the blood vessels and blood viscosity,blood vessels,radius,etc.-Nerve-fluid system on blood pres
4、sure regulation。main centreganglionVascular smooth muscleclonidine-methyldopaEplerenonemecamylamineReserpineguanethidine propranolol 1prazosin 1 labetalolhydralazine sodiumnitroprussidenifedipineminoxidil1.Nervous regulation:the sympathetic nervous systemPeripheral neurotransmitter releaseThe postsy
5、naptic membrane receptorSecond,humoral regulation:renin angiotensin aldosterone systemKidney adjacent ballBeside the machine-R-R blockersreninAngiotensin originalangiotensininvertaseACEIangiotensin Small artery contractionlosartanAldosterone secretionWater sodium retentiondiuretic(thiazides)Classifi
6、cationDiureticThe sympathetic nervous depressants(1)central blood pressure medication(2)the ganglion block(3)noradrenaline can nerve endings block(4)the adrenaline receptor blockersAffect the renin-angiotensin system medicineA gleam of antihypertensives:diuretic,calcium antagonist medicine,beta rece
7、ptor blockers and ACEIDiureticOn the basis of(a line)blood pressure medicationEffect in the thiazide diuretic is most commonly used,antihypertensive effect is mild,persistent,long-term application of no significant resistanceFeatures:Antihypertensive effect is weak,by an average of 10%2 3 weeks afte
8、r the majority of patients in medical workCan be used for various high blood pressure(basic blood pressure medication)Mild-alone,medium and severe-shareCan make the elderly hypertension patients complicated with stroke,the incidence of left heart failure and mortality is leftHydrochlorothiazideEarly
9、 antihypertensive mechanismWith sodium diuresis,reduce the extracellular fluid and blood volumeLong-term antihypertensive mechanismDiuretic row sodium to Na+left aortic smooth muscle cell,cell Na+/Ca2+exchange left-intracellular Ca2+left,reduce vascular smooth muscle of norepinephrine(NE)reactivityd
10、isadvantages:-Blood K+、Na+、Mg2+-Blood total cholesterol,triglyceride,low density lipoprotein cholesterol(hdl-c)-Blood uric acid -Blood renin -Glucose tolerance(disabled)for diabetes patientsEffective diuretic(furosemide)used in hypertensive crisis and poor associated with chronic renal hypertension
11、patients.Hypertensive crisis Patients with high blood pressure in the short term,the blood pressure increased significantly,and appear have a headache,be agitated,palpitation,sweating,nausea,vomiting,or pale flush,blurred vision and other signs.Mechanism:hyperthyroidism and circulating catecholamine
12、s increased sympathetic nervous activityClinical applicationA gleam of medicationApplication of the treatment for mild hypertension separatelyWith other antihypertensive drug treatment,severe hypertensionEffect of diuresis medicine of compound preparations with other drugsCompound antihypertension t
13、ablet:give up ping,hydralazine,hydrochlorothiazideCompound apocynum tablet:guanidine b organism,hydralazine,hydrochlorothiazideJane chrysanthemum antihypertension tablet:clonidine,hydrochlorothiazideCompound captopril tablets,enalapril and hydrochlorothiazideConstant dropping pills:clonidine,hydrala
14、zine,hydrochlorothiazideCalcium antagonist medicine Block L voltage dependent calcium channel-left intracellular Ca2+diastolic small arteryNifedipine group,horizon,lacidipine flat,amlodipineNifedipine【Step-down characteristics】1 Buck degree was positively correlated with the original high blood pres
15、sure,with normal blood pressure has no obvious antihypertensive effect;2 Oral absorption is good,work fast:sublingual administering 1-5 minutes work-in the treatment of variant angina pectoris,hypertensive crisis.Oral 30 to 60 minutes work-treatment of mild and moderate hypertension;3 Can cause refl
16、ective heart rate share Receptor blockers.Clinical applicationLight,medium and severe hypertension treatmentNitrendipineSelectively ACTS on the peripheral vascular,blocking its internal flow of calcium ions,relaxing smooth muscle,the dilate blood vessels and step-downWarm and lasting antihypertensiv
17、e effect,applicable to various types of high blood pressureLacidipineIs a potent calcium antagonists,significantly and the effect of selective calcium ion channels in vascular smooth muscle.Its main role is to expand peripheral artery,reduce peripheral vascular resistance and to lower blood pressure
18、Resistance to atherosclerosisUsed for mild and moderate hypertensionName of commodity:lacidipine AmlodipineMore gentle,smooth effect lasting,convenience of once-daily dosage,24 hours of stability control of high blood pressure and angina pectoris,good safety and tolerabilitySimilar drugs,only it can
19、 be used by patients with congestive heart failure safetyAlso has the role of atherosclerosisAdrenaline receptor blockers Receptor blockers:prazosin、terazosin、doxazosin Receptor blockers:prapranolol、atenolol、labetalol、carbedilolMechanism of actionNonselective beta receptor blockers,mostly related wi
20、th the beta blocker:Heart:myocardial contraction force is abate,slow heart rate,cardiac output decreasesKidney:reduce renin secretion,inhibit RAS on blood pressure regulationThe sympathetic nerve endings presynaptic membrane:inhibition of positive feedback,NA secretion declineCentral(hypothalamus an
21、d medulla oblongata):excitatory neuron activity is abate,peripheral sympathetic nerve tension by,vascular resistance decreasedIncrease the top ring element synthesisClinical applicationSuitable for various high blood pressureWith high cardiac output or plasma renin levels has good effect on the high
22、 side of hypertensive patients,especially suitable for hypertensive patients with coronary heart disease,cerebrovascular diseaseDiuretic or pooling vasodilators can enhance curative effectatenololSelective beta 1 receptor blockers,lack of internal to the sympathetic activityOral is used to treat var
23、ious degree of high blood pressure,antihypertensive effect a longer durationlabetalol、Receptor blockersApplicable to various degrees of hypertension and hypertensive emergency,gestational hypertension,pheochromocytoma,high blood pressure when anesthesia or surgerycarvedilol)、Receptor blockersUsed in
24、 the treatment of mild and moderate hypertension with renal insufficiency,diabetes,high blood pressure patientsRenin angiotensin system depressants ACEI:Captopriletc.AT1-resistance:Chlorinesand,valsartan,etc【Antihypertensivemechanism】1.AngII Generate and function。Arteriovenous diastolic Peripheral r
25、esistance Blood pressure;Block the release of aldosterone water sodium retention;2.Inhibition of slow excitation peptide degradation Slow excitation peptide concentrations in the blood:produce NO、PG2Etc.血管扩张血管扩张血压血压 AngiotensinconvertingenzymeinhibitorsACEI captopril(Asulfhydrylpropionicacidpulp)【Fu
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