第九章-固有免疫的组成细胞课件.ppt

1、抗体抗体补体补体 CD16（Fcg gR III）CD11b/CD18 CD25CD28 CD32（Fcg gR II）CD35（CR1）CD64（Fcg gR I）CD71B7-2IL-2抗体抗体补体补体 抗体抗体运铁运铁蛋白蛋白吞 噬 细 胞 表 面 受 体Alveolar macrophages(lung)Histiocytes(connective tissue)Kupffer cells(liver)Mesangial cells(kidney)Microglial cells(brain)Tissue macrophage Figure 1.6ijMacrophages are i

2、mportant first responders to infection and tissue damage.CLCLCLCLCLCLCLCLF2 NH2 CRDCOOHSSCOOH COOHHOOCNH2NH2 2HNS 甘露糖受体 除杂受体巨 噬 细 胞 受 体吞噬细胞的作用n吞噬杀伤和消除作用：n通过受体识别异己吞噬吞饮杀灭异物n分泌细胞因子和其他炎症物质：nTNF、IL-1、6、8、12、MCP-1及前列腺素 n等局部血管扩张通透性增加，激活血管内 n皮细胞表达粘附分子，吸引吞噬细胞n作为APC：n加工处理提呈抗原，启动特异性免疫应答They are the earliest ph

3、agocytic cells to appear in the bacterial infection and are prominent constituent of pus.Blood film showing a monocyte(left)and two neutrophilsAlveolar(Lung)Macrophage Attacking E.coli(SEM x10,000)Adherence of bacteria via receptorsA.Respiratory burst:Oxygen-dependent,myeloperoxidase-independent rea

4、ctionsB.Respiratory burst:Oxygen-dependent,myeloperoxidase-dependent reactionsNitric oxide-dependent killing静息状态（静息状态（resting state）活化状态（活化状态（primed state）-IFN-g亢奋状态（亢奋状态（activated state）-C3b+LPS+IFN-gnNK细胞受体：n 杀伤细胞活化受体n (killer activatary recepter,KAR)n能够识别和结合自身组织细胞、病毒感染细胞和某些肿瘤细胞表面的糖类配体 Ig样受体：NKp46

5、、NKp44、NKp30。凝集素样受体：NKC-P1.免疫受体酪氨酸活化基序(immnoreceptor tyrosine-based activation motif，ITAM)：免疫细胞活化受体胞浆区共有的以酪氨酸残基为基础的基序，含有此类基序的膜受体能够转导细胞活化信号。杀伤细胞抑制受体 (killer inhibitory recepter,KIR)胞膜外区能够识别表达于自身组织细胞表面的MHC-I类分子,胞浆内区能够介导抑制信号的产生。凝集素样受体：CD94/NKG2 Ig样受体：(3)两种受体对NK细胞杀伤作用的调节Function in disease,not entirely

6、understoodContains high affinity receptors for IgE,and preformed granules that contain inflammatory mediators including:histamine;heparin;TNFa;chondroitin sulfate;neutral proteases;and other.Mast cells can also secrete:cytokines to induce inflammation;chemokines to induce infiltration by monocytes,and neutrophils,leukotriences to induce muscle contraction and increase vascular permeabilityMast cells are capable of inducing an inflammatory cascade其他固有免疫细胞其他固有免疫细胞