口腔粘膜病诊断和治疗措施课件整理.ppt
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- 口腔粘膜 诊断 治疗 措施 课件 整理
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1、IntroductionBehets diseaseTraumatic Ulcer&Traumatic BullaRecurrent Aphthous UlcerSummary&QuestionsBACKReiters Syndrome I.IntroductionUlcers are one of the most common types of lesions seen in oral mucosa.2.The difference between ulcer and erosion.NEXTulcererosionNEXTulcererosioncontinuity of epithel
2、iumbroken severesuperficial basal cellsinvolvedfreeborderclearuncleardiseasesRAUBehcets diseaseSyphilis PemphigusHerpes simplex BACKComparison Recurrent Aphthous Ulcer1.Preface Name recurrent aphthous ulcer RAU recurrent aphthous stomatitis RAS recurrent oral ulcer ROUNEXT Typing Lehners classificat
3、ion minor aphthous ulcer(MiAU)major aphthous ulcer(MjAU)herpetiform ulcer(HU)Characteristic recidivity self-healing periodicityNEXT2.Etiology unknown immunity:cellular immunity,humoral immunity,complement,autoantibody heritage infection:HSV environment:psychologyNEXT denutrition:iron,copper,zinc,fol
4、ic acid,Vit B12 hyperoxide dismutase microcirculation disturbance:lip,nail,apex linguae systemic factor:ulceration of stomach、hepatitis、colonitis、diarrhoeaNEXT3.Clinical features minor aphthous ulcer major aphthous ulcer herpetiform ulcerNEXTNEXTMiAUMjAUHUfeatureyellow red concave painful small(2-4m
5、m)big(1-3cm)deep scarmultiple smallcourse7-10 days3-6 weeks7-10 daysnumber 1-51 10positionnonkeratinized oral mucosa soft palatetongue lip mouth floorsystemic symptomlymph nodes swelling fever headache lymph nodes swelling Minor aphthous ulcersNEXTNEXTNEXTMiAUMjAUHUfeatureyellow red concave painful
6、small(2-4mm)big(1-3cm)deep scarmultiple smallcourse7-10 days3-6 weeks7-10 daysnumber 1-51 10positionnonkeratinized oral mucosa soft palatetongue lip mouth floorsystemic symptomlymph nodes swelling fever headache lymph nodes swelling Major aphthous ulcers NEXT Periadenitis Mucosa Necrotica Recurrens
7、NEXTMajor aphthous ulcers NEXTMiAUMjAUHUfeatureyellow red concave painful small(2-4mm)big(1-3cm)deep scarmultiple smallcourse7-10 days3-6 weeks7-10 daysnumber 1-51 10positionnonkeratinized oral mucosa soft palatetongue lip mouth floorsystemic symptomlymph nodes swelling fever headache lymph nodes sw
8、elling Herpetiform ulcers NEXTdisease-process24h10d-14doutbreakNEXTintermissionhealingprodromal stageulcerative stage5.Diagnosis history clinical featureNEXT4.Pathology:nonspecific inflammation6.Differential diagnosis benign ulcer&malignant ulcer Necrotizing sialadenometaplasia,Behets disease,herpes
9、 simplex,hand-foot-and-mouth disease NEXTbenign ulcermalignant ulcerageyouththe ageddepthdeepDeep or shallowself-healingyesnosystemic conditiongoodcachexypathologychronic inflammationcancerrecurrenceyesnoComparison NEXT7.Treatmentprinciple:symptomatic treatmentEvaluation of curative effectNEXTTopica
10、l application of a steroid ointment reduces discomfort and decreases the duration of the lesions.Topical anesthetics,antibiotics,mouthwashes,etc.,have been used.In severe cases,intralesional steroid injection or systemic steroids in a low dose(10-20 mg prednisone)for 5-10 days reduce the pain dramat
11、ically.BACKIII.Behets disease1.Preface Hulusi Behet (1937)Behets disease is a chronic multisystemic inflammatory disorder of uncertain cause and prognosis.2.Etiology Unknown NEXT3.Clinical features 1)oral mucosa:minor aphthous ulcer 2)genital lesion:ulcer 3)skin lesions:erythema nodosum,epifolliculi
12、tis,pustule after needling 4)ocular lesions:conjunctivitis,recurrent iritis 5)others systems:joint,digestive,cardiovascular,nervous,respiratory,urinaryNEXTBehets diseaseNEXT4.Pathology:Histopathologic changes consist of a perivascular mononuclear cellular infiltrate,endothelial cell swelling or necr
13、osis,partial luminal obliteration and occasional fibrinoid necrosis of the vessels.NEXT5.Diagnosis 1)recurrent oral ulceration 2)recurrent genital ulceration 3)eye lesions 4)skin lesions 5)positive pathergy test To establish the diagnosis of Behets Disease,recurrent oral ulceration plus any two of t
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