《医学免疫学教学》03-antibody课件.ppt
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- 医学免疫学教学 医学 免疫学 教学 03 antibody 课件
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1、Outline of the lectureEmil von Behring(1845-1917)antibody-In 1890 by von Behring and Kitasato described an activity in serum of toxin-immunized animals that neutralized toxin.Transfer of immune serum could protect nave animals from diphtheria or tetanus.HistoryDay 02468Resting B cellAntibodyforming
2、cell,AFC(plasma cell)YYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYOutline of the lecturenBasic structurenHeavy chain and Light chain(重链和轻链)(重链和轻链)nVariable region and Constant region(可变区和恒定区)(可变区和恒定区)nOther structuresnHinge region(铰链)(铰链)nJoining chain(J链)链)n Secretory component(SC,分泌片,分泌片)nDomains(功能区)(功能区)nFr
3、agmentation of Ig by proteolytic cleavage人:人:2:1,小鼠:,小鼠:20:1 1)Heavy chain(H)&Light chain(L)2)Variable region(V region)and constant region(C region)V regions(VL+VH)are the site where antigens bind specifically to antibodies.Fab(antigen binding fragment)are the N-terminal half of the H-chain and all
4、of the L-chain.Fc(crystallized fragment)are the C-terminal half of the H-chain fragment that crystallized).FabFcHypervariable regions(HV,CDR)and framework regions(FR)Domains of Ig 3)Other structures(1)Hinge region Flexibility of immunoglobulinsJoining chain aid to combine monomers into polymers.Five
5、 molecules of IgM usually polymerize into a larger pentamer.Secretory IgA is a dimmer.Secretory component(SC)can prevent the secretory IgA dimmers from degradation of other proteases.Secretory IgA always distribute on lumenal surface.(2)Joining chain and secretory component(SC)Secretory IgA is a dim
6、merIgM polymerize into a pentamerBoth H-and L-chains have intrachain disulfide bridges every 90 amino acid residues,which create polypeptide loops,domains,of 110 amino acids.免疫球蛋白的功能区免疫球蛋白的功能区-H chain Variable region is one domain,referred to as VH;constant region has three or four domains,referred
7、to as CH1,CH2,CH3,CH4.(IgG,IgA,IgD has three domains-CH1,CH2,CH3 in C region;while IgM,IgE has four domains-CH1,CH2,CH3,CH4 in C region).-L-chain Variable region is one domain,referred to as VL;constant region also has only one domain,referred to as CL.3.Immunoglobulin fragmentsOutline of the lectur
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