D-二聚体在肺栓塞中的应用-英文课件.ppt

1、D-dimer in Pulmonary embolismThe 1st Hospital Of Jilin UniversityZhenggiu WangOutlineOutlineD-dimer assays Methods D-dimer cut-off and AgeD-dimer and Clinical ProbabilityD-dimer and anticoagulationD-dimer in Other diseasesFormation of D-dimer Part I Formation of D-dimer Part II D-dimer MethodsSensit

2、ivity and specificity of different D-dimer assaysRole of D-dimer in VTE;Imaging Decisions 3/2007D-dimer Methods Part III D-dimer and Clinical Probability in Suspected PED-dimer and Clinical Probability in Suspected PEAcute Pulmonary Embolism；Curr Probl Cardiol 2010;35:314-376.Arch Intern Med.2004;16

3、4:2483-2487 D-dimer and Clinical Probability in Suspected PEThe cut-off of D-dimer in VTEArch Intern Med.2004;164:2483-2487D-dimer and Clinical Probability in Suspected PE Part IV D-dimer and anticoagulation D-dimer concentration and anticoagulant therapyNEJM2006;355;1780-9;D-dimer Testing to Determ

4、ine the Duration of Anticoagulation Therapy曲线曲线1曲线曲线2曲线曲线3 Part IV D-dimer and anticoagulationBaseline characteristics：年纪更大、并发症更多、年纪更大、并发症更多、随访时间更长随访时间更长 Part IV D-dimer and anticoagulationFigure 3.Cumulative incidence and hazard ratios(HRs)of main outcomes according to D-d time course from the thir

5、d month(T90)to the 13th month(T390).Group 1:Patients in whom D-d was normal at T90 and afterward (with D-d becoming abnormal only once).Group 2:Patients in whom D-d became abnormal at T90 and afterward remained altered persistently or at least twice.Group 3:Patients in whom D-d became abnormal after

6、 T90 and afterward remained abnormal persistently or at least twice.NEJM,356;4;January 2007;D-dimer and anticoagulationThe cut-off of D-dimer in VTE D-dimer and recurrent VTE Part II D-dimer and Age D-dimer and recurrent VTED-dimer and recurrent VTE Part V D-dimer cut-off and AgeD-dimer in Pulmonary

7、 embolismThe 1st Hospital Of Jilin UniversityAcute Pulmonary Embolism；Curr Probl Cardiol 2010;35:314-376.Acute Pulmonary Embolism；Curr Probl Cardiol 2010;35:314-376.Fatal PE according to AgeFigure 1:Distribution of D-dimer results for age groups(a)80years.A D-dimer result is reported as negative if

8、below 500ng/ml,showed by bold ventical line.D-dimer assay in the elderlyInternal Medicine Journal 37(2007)607-613D-dimer and AgeD-dimer and AgeD-dimer and AgeD-dimer and Age Part VI D-dimer in other diseases Part V D-dimer in CanerAcute Pulmonary Embolism；Curr Probl Cardiol 2010;35:314-376.D-dimer and cancer D-dimer and F1+2 levels in Different sites of cancerThe cut-off of D-dimer in VTEElevated D-dimer+(F1+2)Elevated(F1+2)Elevated D-dimerNonelevated D-dimer+(F1+2)D-dimer and cancer Part VI D-dimer in other diseasesD-dimer for Acute Aortic Dissection