免疫应答概论课件.ppt
- 【下载声明】
1. 本站全部试题类文档,若标题没写含答案,则无答案;标题注明含答案的文档,主观题也可能无答案。请谨慎下单,一旦售出,不予退换。
2. 本站全部PPT文档均不含视频和音频,PPT中出现的音频或视频标识(或文字)仅表示流程,实际无音频或视频文件。请谨慎下单,一旦售出,不予退换。
3. 本页资料《免疫应答概论课件.ppt》由用户(晟晟文业)主动上传,其收益全归该用户。163文库仅提供信息存储空间,仅对该用户上传内容的表现方式做保护处理,对上传内容本身不做任何修改或编辑。 若此文所含内容侵犯了您的版权或隐私,请立即通知163文库(点击联系客服),我们立即给予删除!
4. 请根据预览情况,自愿下载本文。本站不保证下载资源的准确性、安全性和完整性, 同时也不承担用户因使用这些下载资源对自己和他人造成任何形式的伤害或损失。
5. 本站所有资源如无特殊说明,都需要本地电脑安装OFFICE2007及以上版本和PDF阅读器,压缩文件请下载最新的WinRAR软件解压。
- 配套讲稿:
如PPT文件的首页显示word图标,表示该PPT已包含配套word讲稿。双击word图标可打开word文档。
- 特殊限制:
部分文档作品中含有的国旗、国徽等图片,仅作为作品整体效果示例展示,禁止商用。设计者仅对作品中独创性部分享有著作权。
- 关 键 词:
- 免疫 应答 概论 课件
- 资源描述:
-
1、免疫应答概论免疫应答概论2 light chains(or)2 heavy chains(5 isotypes:IgG,M,A,D,E)2 Binding sites(Divalent)Secreted into circulationBinds Soluble Antigen2 Chains/(95%)or/(5%)1 Binding site(Monovalent)Membrane Bound,Not SecretedBinds Antigen Complexed with MHCZap 70fynlck e ez zV V C C CH1CH2CH3CH2CH3CH1CLCLVLVLVH
2、VHe e z zIg/IgIg/IgBlk,Fyn or LynB and T Lymphocyte Antigen ReceptorsBDC2020/11/42XPID:X-linked polyendocrinopathy,immune dysfunction and diarrhea XLAAD:“Autoimmunity Allergic Dysreg”Scurfin gene(Foxp3/JM2)Immunopathogenesis:Th2 Cytokines,abnormal activation(Il-4,5,13)-Scurfy+Nude:No Autoimmunity-CD
3、4+into Nude:Disease-Bone Marrow into irradiated:No Disease-Require Antigen Stimulation for Disease-Mixed Chimera:No DiseaseBDC2020/11/43Human Leukocyte Antigenhuman MHCcell-surface proteinsimportant in self vs.nonself distinctionpresent peptide antigens to T cellsCLASS I:A,B,CCLASS II:DR,DQ,DPHLAJ.N
4、oble2020/11/44The Human Leukocyte Antigen Complex (6p21.31)DP DQ DR B C AClass II (1.1 Mb)Class IIIClass I (2.2Mb)Complement and CytokinesClass I-like genesand pseudogenesFrequent Recombination Recombinationis RareTelomereCentromere Recombinationis Rare(0.7Mb)BDC2020/11/45 3 211 2211221122Binds 8-10
5、mersExpressed on most Nucleated cellsPresents Cytosolic Proteins to CD8+T cellsBinds 13-25mersExpressed on APCs,Macs,B cells,activated T cellsPresents Vesicular Proteins to CD4+T cellsClass IClass IIHLA Class I and II Molecules Have a Distinct Structure and FunctionBDC2020/11/460501 02010301 0302 ci
6、scisDQA1 DQB1transDQA1*0301/DQB1*0201DQA1*0501/DQB1*0302DQA1*0501/DQB1*0201DQA1*0301/DQB1*0302MaternalPaternalCis and Trans-Class II DimerizationBDC2020/11/47DQB1*0402Asp57 Leu56 -chain-chainBDCBDC2020/11/48HLA-Peptide:TCRCDR1CDR2CDR3CDR3CDR2CDR1NH3+COO-TCRalphaTCRbeta2 Helix1 HelixBDC2020/11/49Co-S
7、timulation TCellAPCCTLA-4-CD28+CD154(CD40L)CD2CD58CD40B7(+)IL-1,IL-6,TNFIL-10TGF(-)TCR-MHCBDC2020/11/410Absence of Signal 2ActivationClonal Anergy or DeletionTCRMHCAPCToleranceT CellTCRMHCAPCSignal 1+Signal 2B7T CellcytokinesCD28The 2-Signal Model of Lymphocyte ActivationBDC2020/11/411MHC/self-pepti
8、deCD4MHC/VCD4CD4+V x T cell APCActivated autoreactive CD4+TCR V x TH1 cell TCR VxTCR Vx(1)expansion of CD4+,autoreactive TH1 cells specific for autoantigens(2)migration and infiltration of these self reactive CD4+TH1 cells into tissues and induction of inflammation and autoimmunity(3)induction of re
展开阅读全文