内科学课件33-新版英文RA教学幻灯(应用)AA.pptx

1、RHEUMATOID ARTHRITIS(RA)What is Rheumatoid Arthritis(RA)?Clinical Picture What happened on these joints?PathologyPathology早中期X光表现 进展期X光表现erosionJoints frequently involved Nature of RAExtra-articular Manifestationsischemic necrosis due to vasculitisNeurovascular DiseaseRheumatoid FactorDiagnosis Key

2、points FSmall joints especially hands and wrists are more often involved FSymmetrical or bilateral distributionFChronic in duration FErosive in X ray filmFdeformityFMorning stiffness in chief complainDifferential DiagnosisSLEManagementsObjective of treatmentMedical TherapyAdverse effects of NSAIDsCO

3、X-1/COX-2 TheoryCOX-1ConstitutiveCOX-2RegulatedPrinciples for DMARDs therapy F1.early use Fbination therapy Common combination therapyFMTX+CQ(HCQ)FMTX+SASPFMTX+LEFBiological agentsFAnti-TNF preparations Infleximab and Etanercept Surgical intervention 1.Synovectomy2.Joint replacement PRINCIPLE OF THERAPYFIndividualized protocol FRisk/benefit evaluationFPatient eduacation Comprehension questionsThank you