静脉全麻技术及其进展课件.pptx

1、Pharmacokinetic properties of Diprivan(propofol)Open,three-compartment modelEffect compartmentCentral compartment 1V1Eliminationk10k12k21Second compartment2k13k31Third compartment3keoDrug equilibrates betweenand within compartmentsIntravenous infusionk1e血浆峰效应血浆初始峰效应CCVVd1 kteCCt0)(tBetAeCt)()1(.0kte

2、kVdRCtktekVdRCss.0peakeffectp,initialp,1peakeffectCCVVCLSCtQT)()3121()(1312101tkektkekkVCtQt单次注药后三室模型的血浆浓度变化单次注药后三室模型的血浆浓度变化在快速分布相，药物从中央室（V1）向快速周边室（V2）、慢速周边室(V3)和体外转运。在慢速分布相，药物从V2向V1，以及从V1向V3和体外转运。在终末相，药物从V2和V3向V1转运，从V1排出returnTCITCI系统输入靶浓度（系统输入靶浓度（15ug/ml)15ug/ml)的硫喷妥钠持续不同时间，停药后的硫喷妥钠持续不同时间，停药后血药浓度的恢复血药浓度的恢复100%CpCpCmPETNijMDPEiPEijmedianwobble,1,Thanks!