南口博纪教授-NEW-IR-for-DVT.ppt
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- 南口博纪 教授 NEW IR for DVT
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1、南口博纪教授-NEW-IR-for-DVTWakayama Medical Univ.Hospital800 Beds1500 Outpatients/dayAngiography 2700/year in all 600/year in IRWakayama 和歌山970,000 in Wakayama Pref.370,000 in Wakayama City高野山KoyasanA.D.816 1,200years old temple白浜Shirahama Adventure WorldBig Panda Family北京北京Acute DVTLymphedemaAfter Hyster
2、ectomyHematomaOverdose of VKAChronic DVTPost-thrombotic Synd.Chief Complaints:Leg SwellingIRRed,Fever,PainfulWhite,pitting edemaBlue,anemiaSkin Ulcer,Infectionhistory of DVTIntroductionVenous Thromboembolism(VTE)=Pulmonary Embolism(PE)+Deep Vein Thrombosis(DVT)PE in 70%of DVT casesDVT in 3070%of PE
3、cases PHLEGMASIA CERULEA DOLENSPE incidence:JAPAN-62/million,USA-500/millionVTE increasing in JAPAN:Westernization of Lifestyle,Aging Population,Greater rate of DiagnosisPE:High mortality 10-30%Over 100,000 deaths/year in USAEarly Diagnosis and Treatment(including inhibition of DVT progression and p
4、revention of PE recurrence)are therefore very important!Treatment of DVT has recently advanced significantlyDespite the use of standard anticoagulant therapy,DVT recurs frequently and often leads to the development of post-thrombotic syndrome(PTS)Catheter-based techniques have been used in the manag
5、ement of DVT for many years,but are undergoing now strict evaluation in RCTs to determine whether they improve patient outcomes70 FAcute DVT2001.1Greenfield filterMicrocath.via jugularExtravasation!From Jugular vein=Retrograde approachVascular Injury may occurWaste of TimeG.OSullivan2 days later,Pop
6、 V approach(1st case)Now 86 years old,alive,no symptoms27 limbs,CDT with UK(1.4 million16.0 million IU)for 30 hr(1574 hr)Technical&clinical success 85%,No major complications.Rationale for Thromboreductive Therapies Consequences of DVTPTS develops in 2550%with proximal DVTPTS causes chronic symptoms
7、(swelling,pain,heaviness,fatigue.)Severe PTS may experience venous claudication,stasis dermatitis,skin changes(hyperpigmentation,fibrosis,skin ulcer)Recurrent ipsilateral DVT:2 to 6-fold increased risk of PTSTherefore,adequate anticoagulation should be a key PTS prevention measure,but it is clear th
8、at despite anticoagulation many DVT patients will still develop PTS.Rajasekhar A:J Thromb Thrombolysis 2015;39,315.IVC filter indicationsNot reportedPREPIC studyPermanent IVC filter&Anticoaglants(AC)vs AC only for Proximal DVT with/without PE,f/uAcute phase:PE preventableChronic phase(8 years):Recur
9、rent DVT is higher!(p0.042)Use retrievable IVC filter&retrieve ASAP!Decousus H,NEJM,338,1998.PREPIC Study Group.Circulation 112,2005.PREPIC 2 studyPE patients:Retrievable IVC filter&AC vs AC onlyAC for 6 months,Filter retrieval 3 months3 months,Recurrent PE in 6 cases vs 3 cases6 months,Recurrent PE
10、 in 7 cases vs 4 cases6 months,Recurrent DVT in 1 case vs 2 casesNo need for IVC filter under adequate ACsStill Controversial!Mismetti P,JAMA 313,2015.Retrievable(optional)filter in almost all cases before Thrombolysis1.IVC filterGunther tulipOptEaseALNTo Prevent iatrogenic PE due to Thrombolysis an
11、d/or ThrombectomyCatheter-directed intrathrombus thrombolysis(CDT)for DVTImage-guided,Catheter-directed,intra-thrombus drug infusion has been safe and effective Advantages:(1)Achieve a high intra-thrombus drug concentration and Avoid bypass of the drug via collaterals(2)Reduce drug dose,treatment ti
12、me and complicationsRequired EquipmentOur standard IR protocol typically requires the following devices:6-F vascular short sheath kit(18-gauge needle,0.035 in guidewire);hydrophilic 0.035 in guidewire;4-F angled-tip multipurpose catheter with multisidehole to cross DVT;5-F pulse-spray catheter6-F th
13、rombectomy catheter with VacLok syringeGuidelines for the Diagnosis,treatment and prevention of DVT(2009)JCS(The Japanese Circulation Society)Acute DVT1.Heparin&VKA(Warfarin)Evidence level2.Systemic ThrombolysisEvidence levela3.CDT and ThrombectomyEvidence levelb4.Stenting after ThrombolysisEvidence
14、 levelbAHA Scientific StatementCDT or PCDT should be given patients with proximal DVT with limb-threatening circulatory compromise(ie,phlegmasia cerulea dolens)(Evidence level I;Grade C)CDT or PCDT is reasonable as first-line treatment with Acute proximal DVT to prevent PTS at low risk of bleeding c
15、omplication(Evidence level IIa;Grade B)Chronic(21days),high risk for bleeding(Evidence level III,Grade B)Jaff MR,et al:Circulation 2011.Recent major trials of CDT for DVTCaVenTOpen RCT200Iliofemoral DVT 21 daysCDTAnticoagulationrt-PA6 month patencyPTS at 24 monthsATTRACTOpen multicenter RCT692Iliac,
16、CF,SF DVT 14daysPMT+CDTAnticoagulationrt-PAPTS at 24 monthsDUTCH-CAVAAssessor-blindedmulticenter RCT 180Iliofemoral DVT 14daysUS accelerated CDTAnticoagulation?PTS at 12 monthsStudyDesignNPathologyArmsTherapyPrimary endNov 2009-Jan 2015May 2010-Jan 2015Jan2006Dec 2009CaVenT study from NorwayStandard
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