十二章葡萄膜疾病课件.ppt
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1、The second hospital of Medical college,Xian Jiaotong UniversityThe second hospital of Medical college,Xian Jiaotong University第十二章葡萄膜疾病第十二章葡萄膜疾病UVEA DISEASES 1The second hospital of Medical college,Xian Jiaotong UniversityThe second hospital of Medical college,Xian Jiaotong University一、概述一、概述o 葡萄膜由于
2、富含血管和色素组织故又称葡萄膜由于富含血管和色素组织故又称血管膜或色素膜。血管膜或色素膜。o 包括虹膜、睫状体、脉络膜,故病变相包括虹膜、睫状体、脉络膜,故病变相互影响。互影响。o 葡萄膜病是常见病,以炎症最为常见。葡萄膜病是常见病,以炎症最为常见。2The second hospital of Medical college,Xian Jiaotong UniversityThe second hospital of Medical college,Xian Jiaotong University概述概述o 多发于青壮年,常合并糸统性自身免疫多发于青壮年,常合并糸统性自身免疫性疾病,病情反复
3、,常引起严重的并发性疾病,病情反复,常引起严重的并发症。症。o 病程:小于病程:小于3个月为急性个月为急性 大于大于3个月为慢性。个月为慢性。3The second hospital of Medical college,Xian Jiaotong UniversityThe second hospital of Medical college,Xian Jiaotong Universityo按解剖部位分类按解剖部位分类n 前葡萄炎前葡萄炎Anterior uveitisn 中间部葡萄炎中间部葡萄炎Intermediate uveitisn 后匍萄膜炎后匍萄膜炎Posterior uveit
4、isn 全葡萄膜炎全葡萄膜炎Generalized uveitis概述概述4The second hospital of Medical college,Xian Jiaotong UniversityThe second hospital of Medical college,Xian Jiaotong University二、前葡萄膜炎二、前葡萄膜炎Anterior uveitiso概述概述:n 包括虹膜炎、虹膜睫状体炎和前部睫状体包括虹膜炎、虹膜睫状体炎和前部睫状体三种类型三种类型n 是最常见类型,占我国葡萄膜炎总数的是最常见类型,占我国葡萄膜炎总数的50%-60%n 病因:大多数为内源
5、性,例如细菌、病毒、病因:大多数为内源性,例如细菌、病毒、风湿性疾病等,其次与外伤及手术有关风湿性疾病等,其次与外伤及手术有关5The second hospital of Medical college,Xian Jiaotong UniversityThe second hospital of Medical college,Xian Jiaotong University前葡萄膜炎前葡萄膜炎o症状:症状:n 刺激症状:眼痛、畏光、流泪、刺激症状:眼痛、畏光、流泪、视物模糊视物模糊n 视力下降视力下降6The second hospital of Medical college,Xian
6、Jiaotong UniversityThe second hospital of Medical college,Xian Jiaotong Universityo体症体症:n 睫状或混合性充血睫状或混合性充血n 角膜后沉着物角膜后沉着物KPn 房水闪辉房水闪辉Aqueous flaren 房水细胞房水细胞n 虹膜改变虹膜改变n 瞳孔改变瞳孔改变n 晶状体改变晶状体改变n 眼后段改变眼后段改变前葡萄膜炎前葡萄膜炎7The second hospital of Medical college,Xian Jiaotong UniversityThe second hospital of Medi
7、cal college,Xian Jiaotong Universityn 睫状或混合性充血睫状或混合性充血前葡萄膜炎前葡萄膜炎-体征体征8The second hospital of Medical college,Xian Jiaotong UniversityThe second hospital of Medical college,Xian Jiaotong Universityn 角膜后沉着物角膜后沉着物o 定义:炎症细胞或色素沉积在角定义:炎症细胞或色素沉积在角膜后表面被称为膜后表面被称为KP,其形成需,其形成需要角膜内皮损伤和炎性细胞或色要角膜内皮损伤和炎性细胞或色素细胞的同时
8、存在素细胞的同时存在o 分类:分类:粉尘状粉尘状KP(淋巴淋巴/浆浆)羊脂状羊脂状KP(类上皮类上皮/巨噬巨噬)色素性色素性KP前葡萄膜炎前葡萄膜炎体征体征9The second hospital of Medical college,Xian Jiaotong UniversityThe second hospital of Medical college,Xian Jiaotong University10The second hospital of Medical college,Xian Jiaotong UniversityThe second hospital of Medical
9、 college,Xian Jiaotong Universityn 房水闪辉房水闪辉Aqueous flare:在炎症时虹膜睫状体的血管扩张,大在炎症时虹膜睫状体的血管扩张,大量的蛋白质或纤维素成分及炎性细胞渗出量的蛋白质或纤维素成分及炎性细胞渗出至房水中使房水变得混浊不清至房水中使房水变得混浊不清前葡萄膜炎前葡萄膜炎体征体征11The second hospital of Medical college,Xian Jiaotong UniversityThe second hospital of Medical college,Xian Jiaotong Universityn 前房细胞:
10、前房细胞:o 主要为炎性细胞主要为炎性细胞o 裂灯下表现为大小裂灯下表现为大小一致的灰白色颗粒一致的灰白色颗粒o 炎性细胞运动规律炎性细胞运动规律o 前房积脓前房积脓Hypopyon前葡萄膜炎前葡萄膜炎体征体征12The second hospital of Medical college,Xian Jiaotong UniversityThe second hospital of Medical college,Xian Jiaotong Universityn 虹膜改变:虹膜改变:o 虹膜后粘连虹膜后粘连Posterior synechia of the iriso 虹膜膨隆虹膜膨隆Iri
11、s bombeo 虹膜前粘连虹膜前粘连Anterior synechia of the iriso 房角粘连房角粘连Goniosynechia前葡萄膜炎前葡萄膜炎体征体征虹膜后粘连虹膜膨隆,房角粘连13The second hospital of Medical college,Xian Jiaotong UniversityThe second hospital of Medical college,Xian Jiaotong Universityn 瞳孔改变:瞳孔改变:o 梅花状、梨状、梅花状、梨状、不规状瞳孔不规状瞳孔o 瞳孔闭锁瞳孔闭锁Seclusion of pupilo 瞳孔膜闭瞳
12、孔膜闭Occlusion of pupil前葡萄膜炎前葡萄膜炎体征体征14The second hospital of Medical college,Xian Jiaotong UniversityThe second hospital of Medical college,Xian Jiaotong Universityn 晶状体改变:晶状体改变:o晶体表面环形色素晶体表面环形色素o晶体表面斑块状色素晶体表面斑块状色素n 眼后段改变:眼后段改变:o前玻璃体炎性细胞前玻璃体炎性细胞o偶见反应性黄班囊样水偶见反应性黄班囊样水肿或视盘水肿肿或视盘水肿前葡萄膜炎前葡萄膜炎体征体征15The sec
13、ond hospital of Medical college,Xian Jiaotong UniversityThe second hospital of Medical college,Xian Jiaotong Universityo 前葡萄膜炎并发症前葡萄膜炎并发症n 继发性青光眼:继发性青光眼:n 并发性白内障并发性白内障n 低眼压和眼球蒌缩低眼压和眼球蒌缩前葡萄膜炎前葡萄膜炎16The second hospital of Medical college,Xian Jiaotong UniversityThe second hospital of Medical college,X
14、ian Jiaotong Universityo诊断诊断Diagnosis:n 诊断依据:睫状充血;诊断依据:睫状充血;KP;房水闪辉;瞳;房水闪辉;瞳孔缩小;虹膜后粘连。其中以孔缩小;虹膜后粘连。其中以KP和房水闪和房水闪辉阳性最为重要辉阳性最为重要n 仅有虹膜后粘连、晶体前表面色素沉着,有仅有虹膜后粘连、晶体前表面色素沉着,有虹睫炎病史,而无睫状充血、虹睫炎病史,而无睫状充血、KP和房水闪和房水闪辉等活动性病变则诊断为陈旧性虹睫炎辉等活动性病变则诊断为陈旧性虹睫炎n 病因诊断困难,注意有无关节、消化道和免病因诊断困难,注意有无关节、消化道和免疫性疾病疫性疾病前葡萄膜炎前葡萄膜炎17The
15、second hospital of Medical college,Xian Jiaotong UniversityThe second hospital of Medical college,Xian Jiaotong University签别诊断签别诊断 急性结膜炎急性结膜炎 虹睫炎虹睫炎 急闭青光眼急闭青光眼 充血充血 结膜性结膜性 睫状睫状/混合混合 混合性混合性角膜角膜 透明透明 透明透明KP 水肿水肿瞳孔瞳孔 正常正常 小小 大大眼压眼压 正常正常 大多正常大多正常 高高前葡萄膜炎前葡萄膜炎18The second hospital of Medical college,Xian
16、 Jiaotong UniversityThe second hospital of Medical college,Xian Jiaotong Universityo治疗治疗Treatment-散大瞳孔散大瞳孔n 目的目的:o 防止虹膜后粘连、瞳孔闭锁,以减少继发性青光防止虹膜后粘连、瞳孔闭锁,以减少继发性青光眼眼o 解除或减少虹膜括约肌和睫状肌痉挛,使其处于解除或减少虹膜括约肌和睫状肌痉挛,使其处于休息状态,刺激症状减轻,有利于病情的恢复。休息状态,刺激症状减轻,有利于病情的恢复。o 促进睫状体的血液循环促进睫状体的血液循环前葡萄膜炎前葡萄膜炎19The second hospital o
17、f Medical college,Xian Jiaotong UniversityThe second hospital of Medical college,Xian Jiaotong Universityn 常用药物:常用药物:o 炎症活动期给予炎症活动期给予 2%后马托品眼膏后马托品眼膏1836ho 瞳孔散不大时给予强散瞳剂瞳孔散不大时给予强散瞳剂0.2ml结膜下注射结膜下注射o 炎症恢复期给予托品酰胺滴眼液炎症恢复期给予托品酰胺滴眼液前葡萄膜炎治疗前葡萄膜炎治疗20The second hospital of Medical college,Xian Jiaotong Univers
18、ityThe second hospital of Medical college,Xian Jiaotong Universityn 局部局部o 0.5%考的松滴眼液点眼考的松滴眼液点眼o 庆大霉素庆大霉素2万万u十地塞米松十地塞米松 5mg结膜下注射结膜下注射n 全身全身o 0.9%NS250ml+D.X.M10mg静脉滴注静脉滴注o 强的松:强的松:20mg,q.d.前葡萄膜炎前葡萄膜炎-治疗治疗21The second hospital of Medical college,Xian Jiaotong UniversityThe second hospital of Medical c
19、ollege,Xian Jiaotong Universityn 抗前列腺素类药物:抗前列腺素类药物:o 阿斯匹林阿斯匹林0.5 tido 消炎痛消炎痛25mg tidn 病因治疗:病因治疗:o 感染感染抗菌素抗菌素o 结核结核抗结核抗结核前葡萄膜炎前葡萄膜炎-治疗治疗22The second hospital of Medical college,Xian Jiaotong UniversityThe second hospital of Medical college,Xian Jiaotong Universityn 并发症治疗并发症治疗o 瞳孔阻滞导致的青光眼瞳孔阻滞导致的青光眼虹膜根
20、切术虹膜根切术o 房角堵塞导致的青光眼房角堵塞导致的青光眼滤过手术滤过手术o 并发性白内障只要光感光定位准确并发性白内障只要光感光定位准确 ECCE+IOL或或PHACO+IOLo 低眼压或眼球萎缩目前尚无有效治疗方法,必要低眼压或眼球萎缩目前尚无有效治疗方法,必要时为维持眼球形态,作羟基磷灰石人工义眼台植时为维持眼球形态,作羟基磷灰石人工义眼台植入。入。前葡萄膜炎前葡萄膜炎-治疗治疗23The second hospital of Medical college,Xian Jiaotong UniversityThe second hospital of Medical college,Xi
21、an Jiaotong University三、中间葡萄膜炎三、中间葡萄膜炎Intermediate uveitiso概述概述n 主要累及睫状体平坦部、玻璃体基底部、周主要累及睫状体平坦部、玻璃体基底部、周边视网膜和脉络膜的炎症性和增殖性疾病边视网膜和脉络膜的炎症性和增殖性疾病n 多见于儿童、多见于儿童、40岁以下年轻人,常累及双岁以下年轻人,常累及双眼,可先后或同时发病眼,可先后或同时发病n 1979年国际葡萄炎研究组命名为中间葡萄年国际葡萄炎研究组命名为中间葡萄膜炎膜炎24The second hospital of Medical college,Xian Jiaotong Univer
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