二章中枢神经系统药物课件.ppt

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关键词：: 中枢神经系统药物课件

资源描述：: 1、ONH3COOHCH3H3PO41 1/2H2O学习要求学习要求授课内容授课内容学习小学习小结结重点难点重点难点ONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2ONHNHOR1R2巴比妥类药物基本结构OOONH3COOHCH3H3PO41 1/2H2O弱酸性水解性与金属离子成盐 ONH3COOHCH3H3PO41 1/2H2O巴比妥类药物酸性比碳酸酸性弱，其钠盐水溶液不稳定，易吸收空气中二氧化碳而析出
2、药物，使溶液呈现浑浊。NHNHOR1R2OONHNOHR1R2OONHNONaR1R2OONaOHH+ONH3COOHCH3H3PO41 1/2H2ONHNONaR1R2OOR1R2NHNH2OOR1R2ONaO+Na2CO3 +NH3NaOHCO2H2OONH3COOHCH3H3PO41 1/2H2ONHNHOR1R2OONHNOAgR1R2OONNOAgR1R2NaOONNOAgR1R2AgOOAgNO3Na2CO3AgNO3ONH3COOHCH3H3PO41 1/2H2ONHNOR1R2OONHNOR1R2OOCuNNONH3COOHCH3H3PO41 1/2H2O化学名为5-乙基-5-
3、苯基-2,4,6(1H,3H,5H)-嘧啶三酮,又名鲁米那。NHHNOOOH3CONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2ONNR4OR1R2R3123456789123456ONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2O化学名为1-甲基-5-苯基-7-氯-1,3-二氢-2H-1,4-苯并二氮杂 -2-酮，又名安定。NNClOCH3ONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2ONNClOCH3NHClCH3NOOHNHClCH3OH2NOHO+
4、H+H+OH-NClCH3ONH2OONH3COOHCH3H3PO41 1/2H2ONHNClOOHONH3COOHCH3H3PO41 1/2H2ONNClNNONH3COOHCH3H3PO41 1/2H2OCCl3OHHOOOH3CH3CONH2ONH2HNOOH3CNOCH3H3C水合氯醛甲丙氨酯格鲁米特甲喹酮ONH3COOHCH3H3PO41 1/2H2ONNONCH3CH3CH3H3CNNNOOONNCH3NCl唑吡坦佐匹克隆ONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2ONHHNOONHNHH3COOONOOCH3H3CCH3HNOOH
5、3CCH2CH3苯妥英扑米酮三甲双酮乙琥胺ONH3COOHCH3H3PO41 1/2H2ONONH2H3COONaH3C卡马西平丙戊酸钠ONH3COOHCH3H3PO41 1/2H2O化学名为5,5-二苯基乙内酰脲钠盐，又名大伦丁钠。NHNOONaONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2ONHNONaO+CO2 +H2ONHHNOO+NaHCO3ONH3COOHCH3H3PO41 1/2H2ONHNONaOHNONH2OOHNH2OOH+NH3NaOHONH3COOHCH3H3PO41 1/2H2ONONH2ONH3COOHCH3H3PO4
6、1 1/2H2OONaH3COCH3ONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2O化学名为N,N-二甲基-2-氯-10H-吩噻嗪-10-丙胺盐酸盐，又名冬眠灵。ONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2ONSClRNSClRO+NSClROHOOONH3COOHCH3H3PO41 1/2H2OFONClOHONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2
7、OONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2O化学名为17-甲基-3-羟基-4，5-环氧-7，8-二脱氢吗啡喃-6-醇盐酸盐三水合物。ONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2OOHONOHCH3HOOHONH3COHONOHCH3O伪吗啡N-氧化吗啡ONH3COOHCH3H3PO41 1/2H2OOHONOHCH3NHOOHH3CHNH3COO阿扑吗啡邻醌化合物（红色）HClOONH3COOHCH3H3PO41 1/2H2OC17H19NO3
8、 K3Fe(CN)6C34H36N2O6 K4Fe(CN)6K4Fe(CN)6 FeCl3Fe4Fe(CN)63 KClONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2O化学名为1-甲基-4-苯基-4-哌啶甲酸乙酯盐酸盐，又名度冷丁。ONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2ONHOCH3CH3CH3CH3ONH3COOHCH3H3PO41 1/2H2OO
9、NH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2ONNNNOCH3CH3CH3咖啡因NNNNHOCH3CH3茶碱HNNNNOCH3CH3可可碱ONH3COOHCH3H3PO41 1/2H2O化学名为1，3，7-甲基-3，7-二氢-1H-嘌呤-2，6-二酮一水合物，又名为咖啡碱。ONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2ONNNNH3COOCH3CH3-OOHOHONH3COOHCH3H3PO41 1/2H2ONNNNH3COOCH3CH3NHNNNH3COOCH3CH3OHNHHNNNH3COCH3
10、CH3NaOHCO2咖啡因咖啡啶ONH3COOHCH3H3PO41 1/2H2ONNOC H3C H3ONO C H3ONON H2O尼可刹米阿尼西坦吡拉西坦茴拉西坦尼可刹米吡拉西坦ONH3COOHCH3H3PO41 1/2H2ONONH2OONH3COOHCH3H3PO41 1/2H2ONH3CHOHOSSNCH3OHOHOONCH3CH3OCl吡硫醇甲氯芬酯ONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2O中枢神经中枢神经系统药物系统药物镇静催眠药抗癫痫药抗精神失常药镇痛药中枢兴奋药ONH3COOHCH3H3PO41 1/2H
11、2O镇静催眠药镇静催眠药巴比妥类苯二氮类其他类基本结构、分类一般性质典型药物构效关系发展、构效关系一般性质典型药物弱酸性、水解性、与金属离子成盐反应苯巴比妥：结构、性质、用途水解性地西泮：结构、性质、用途ONH3COOHCH3H3PO41 1/2H2O抗癫痫药抗癫痫药环内酰脲类二苯并氮类脂肪酸类典型药物苯妥英钠：结构、性质、用途ONH3COOHCH3H3PO41 1/2H2O抗精神失常药抗精神失常药抗精神病药抗抑郁药典型药物盐酸氯丙嗪：结构、性质、用途ONH3COOHCH3H3PO41 1/2H2O镇痛药镇痛药吗啡及其衍生物合成镇痛药构效关系典型药物盐酸吗啡：结构、性质、用途典型药物盐酸哌替啶：结构、性质、用途ONH3COOHCH3H3PO41 1/2H2O中枢兴奋药中枢兴奋药黄嘌呤类酰胺类其他类典型药物咖啡因：结构、性质、用途ONH3COOHCH3H3PO41 1/2H2O

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