子宫腺肌症常见和不常见的MRI表现中英文培训课件.ppt

1、子宫腺肌症常见和不常见的MRI表现中英文On T2-weighted images,typical adenomyosis appears as an ill-demarcated low-signal-intensity lesion with uterine enlargement.However,various physiologic or pathologic states may affect the MR imaging appearance of adenomyosis and may result in a tumorlike appearance 在T2WI上，子宫腺肌症的典

2、型表现为一个边界不清的低信号强度病变伴随着子宫增大。然而，多种生理和病理改变也许会影响子宫腺肌症的MRI表现并且会导致其出现肿瘤样的表现Specific topics discussed are MR imaging manifestations of typical adenomyosis,atypical MR imaging manifestations of adenomyosis,pitfalls in diagnosis of adenomyosis,讨论的具体话题包括子宫腺肌症的典型MRI表现，子宫腺肌症的不典型MRI表现，子宫腺肌症的诊断误区Introduction2子宫腺肌症

3、常见和不常见的MRI表现中英文MR Imaging Manifestations of Typical Adenomyosis子宫腺肌症的典型MRI表现3子宫腺肌症常见和不常见的MRI表现中英文 Typical Adenomyosis At pathologic analysis,adenomyosis is characterized by the presence of ectopic endometrial glands and stroma within the myometrium with hypertrophy and hyperplasia of smooth muscle A

4、denomyosis may affect the uterine myometrium diffusely and result in a diffusely enlarged uterus,or it may be localized as an adenomyoma.病理分析，子宫腺肌症的特征性表现是子宫肌层内异位的子宫内膜腺体和间质的存在和平滑肌的肥大增生。子宫腺肌症也许会弥漫性的影响子宫肌层并导致子宫弥漫性的增大，或者会作为腺肌瘤局限性的影响肌层4子宫腺肌症常见和不常见的MRI表现中英文A cut section of a diffusely adenomyotic uterus s

5、hows thickened myometrium due to the ill-defined adenomyosis;the thickened myometrium is composed of haphazardly distributed hypertrophied muscular trabeculae surrounding ectopic endometrial tissue(Fig 1).Brownish old hemorrhagic foci corresponding to hemolysed blood and hemosiderin pigment deposits

6、 may be contained within the area of adenomyosis弥漫型腺肌型子宫的横断面显示由于界限不清的子宫腺肌病导致肌层增厚。肥厚的肌层是由随意分布的肥大性肌小梁及周围的异位子宫内膜组织所构成（图1）。褐色的旧出血灶也许对应着子宫腺肌症区域内的出血和含铁血黄素沉积 Typical Adenomyosis5子宫腺肌症常见和不常见的MRI表现中英文1A1BFigure 1.Adenomyosis in a 47-year-old woman.47岁女性，子宫腺肌症患者，(a)Photograph of the cut surface of the gross s

7、pecimen shows diffusely thickened myometrium.(b)photomicrograph(hematoxylin-eosin stain)shows ectopic endometrial glands and stroma(arrow)surrounded by hypertrophied smooth muscle.a.大体标本的切面照片显示弥漫性增厚的子宫肌层 b.显微镜下照片（HE染色）显示异位的子宫内膜腺体和间质和周围的肥厚的平滑肌 6子宫腺肌症常见和不常见的MRI表现中英文Typical adenomyosis appears as an il

8、l-demarcated low-signal-intensity area on T2-weighted images owing to abundant smooth muscle proliferation(Fig 2).Because adenomyotic endometrium looks like the basalis endometrium,which seldom responds to hormonal stimuli,cyclic changes including degeneration,bleeding,and regeneration are less comm

9、on in adenomyosis than in endometriosis.子宫腺肌症的典型表现是在T2WI上有一界限不清的低信号区域，这是由于丰富的平滑肌细胞增殖。因为腺肌症子宫内膜跟基底子宫内膜一样，很少对激素的刺激做出反应，所以与其他子宫内膜异位症相比，包括变性，出血，再生这样的周期性的变化较少出现在子宫腺肌症中On T2-weighted MR images,ectopic endometrium appears as small high-signal-intensity areas like normal endometrium(Fig 2).Small cysts may a

10、lso appear as high-signal-intensity spots on T2-weighted images.Sometimes,hemorrhagic foci appear as 13mm high-signal-intensity foci on T1-weighted images owing to the T1-shortening effects of methemoglobin(Fig 2)在T2WI图像上，异位子宫内膜表现为跟正常子宫内膜一样的小的片状高信号，小的囊肿也可能在T2WI上表现为点状高信号。有时候由于高铁血红蛋白T1缩短效应的影响，出血灶在T1WI

11、上表现为1-3mm的高信号病灶 Typical Adenomyosis7子宫腺肌症常见和不常见的MRI表现中英文Susceptibility-weighted imaging is sensitive for old hemorrhagic foci,which appear as spotty signal voids owing to the T2*-shortening effects of hemosiderin.At diffusion-weighted imaging,adenomyosis has low to intermediate signal intensity,a fi

12、nding consistent with its benign,nonneoplastic nature(Fig 3)磁敏感加权成像对陈旧出血灶很敏感，由于含铁血黄素T2缩短效应的影像，表现点状低信号。在弥散加权像上，子宫腺肌症表现为低到中等信号强度，这种表现其实与它是良性，非肿瘤性病变这种性质相一致However,there is no direct correlation between signal intensity at diffusion-weighted imaging and malignancy;most malignant tumors have very high si

13、gnal intensity at diffusion-weighted imaging,a finding that reflects the long T2 relaxation time and restricted diffusion due to high cellularity.然而，DWI上信号强度和恶性病变之间并没有直接的相关性；大多数的恶性肿瘤在DWI上有非常高的信号强度，这反映了由于长的T2弛豫时间和高的细胞密度导致的扩散受限。Typical Adenomyosis8子宫腺肌症常见和不常见的MRI表现中英文Figure 2.Adenomyosis in a 46-year-

14、old woman.46岁女性，子宫腺肌症患者(a)Sagittal T2-weighted fast spin-echo MR image shows an enlarged uterus with an ill-defined low-signal-intensity lesion(arrow)in the posterior myometrium.The lesion contains multiple small high-signal-intensity areas,which represent ectopic endometrial tissue and small cysts.

15、矢状位T2加权快速自旋回波MR图像显示子宫增大，伴随一个子宫肌层后壁内界限不清的低信号强度的病变（箭头处），病变包含多个小的高信号的区域，其代表了子宫内膜异位组织和小囊肿(b)Sagittal T1-weighted spin-echo MR image shows high-signal-intensity spots(arrow),which correspond to some of the small high-signal-intensity areas seen on the T2-weighted image.The high-signal-intensity spots rep

16、resent hemorrhage within the ectopic endometrial tissue.矢状位T1加权自旋回波MR图像显示了点状高信号，它们对应了在T2WI上看到的一些小的高信号区域。这些点状高信号代表了子宫内膜组织内的出血9子宫腺肌症常见和不常见的MRI表现中英文Figure 3.Adenomyosis in a 42-year-old woman.(a)Sagittal diffusion-weighted echo-planar MR image(b=800 sec/mm2)shows an enlarged uterus with an ill-defined

17、lesion of low to intermediate signal intensity(arrow)in the posterior myometrium.(b)Corresponding apparent diffusion coefficient(ADC)map shows no prominent decrease of ADC value in the area of adenomyosis(arrow).a.矢状位扩散加权回波平面MR图像(b=800 sec/mm2)显示增大的子宫伴随后壁肌层内界限不清的病变，呈低到中等信号强度（箭头）。b.相应的ADC图上在子宫腺肌症的区域内

18、没有显示出明显的ADC值的下降10子宫腺肌症常见和不常见的MRI表现中英文Because adenomyosis may show various degrees of enhancement after administration of contrast medium,contrast-enhanced study does not contribute to diagnostic accuracy(Fig 4).Dynamic contrast-enhanced imaging may have greater accuracy than T2-weighted imaging when

19、 adenomyosis and endometrial cancer coexist(16).因为在注射造影剂后，子宫腺肌症可能显示为不同程度的强化，所以关于其对比增强的研究对诊断的准确性没有帮助（图4）。当子宫腺肌症和子宫内膜癌同时存在时动态对比增强图像也许会比T2加权图像更准确However,the heterogeneous enhancement of adenomyosis may cause inaccuracy when evaluating the depth of myometrial invasion by coexisting endometrial cancer;di

20、ffusion-weighted imaging may be helpful in accurately determining the depth of myometrial invasion.然而当并发子宫内膜癌时，子宫腺肌症不均质的强化可能会导致评估肌层浸润深度的不准确；扩散加权成像也许会帮助准确的确定肌层浸润深度 Typical Adenomyosis11子宫腺肌症常见和不常见的MRI表现中英文Diffusion-weighted ImagingDiffusion-weighted imaging allows visualization of the local microstru

21、ctural characteristics of water diffusion.The signal intensity seen on diffusion-weighted images is a combination of the degree of water diffusion and the signal intensity of the underlying T2-weighted images.扩散加权图像能够可视化水分子扩散的微观结构特征，在DWI上看的信号强度是水分子扩散程度和基础T2加权图像信号强度的结合。In oncologic imaging,various ma

22、lignant tumors may show high signal intensity at diffusion-weighted imaging due to their high cellularity and long T2 relaxation time 在肿瘤成像上，由于高的细胞密度和长的T2弛豫时间，各种恶性肿瘤在DWI上显示为高信号。ADC measurement yields quantitative information about tissue structure that is based on the molecular motion of water.Malig

23、nant lesions with increased cellularity show low ADC values,whereas relatively hypocellular benign lesions and normal structures tend to show relatively higher ADC values.ADC图以水分子的运动为基础来测量组织结构的定量信息。高的细胞密度大的病变表现出低的ADC值，而相对低度增生的良性病变和正常组织显示相对高的ADC值 Typical Adenomyosis12子宫腺肌症常见和不常见的MRI表现中英文Figure 4.Aden

24、omyosis in a 47-year-old woman.47岁女性，子宫腺肌症患者(a)Sagittal T2-weighted fast spin-echo MR image shows an enlarged uterus with an ill-defined low-signal-intensity lesion(arrow)in the posterior myometrium.The lesion contains multiple small high-signal-intensity areas.(b)Unenhanced(upper left),early arteri

25、al phase(upper right),late arterial phase(lower left),and venous phase(lower right)images,obtained with a dynamic gadolinium-enhanced three-dimensional fast spoiled gradient-echo sequence with fat suppression,show heterogeneous and gradual enhancement of the lesion.a.矢状位T2加权快速自旋回波MR图像显示子宫增大伴随子宫肌层后壁内

26、界限不清的低信号强度病变。病变内包含多个小的高信号强度区域b.由一个压脂动态钆增强型三维快速小角度梯度回波序列获得平扫（左上图），动脉早期相（右上图），动脉晚期相（左上图），以及静脉相（右下图），病变表现为不均匀和渐进性的强化。13子宫腺肌症常见和不常见的MRI表现中英文Atypical MR Imaging Manifestations of Adenomyosis子宫腺肌症的非典型MRI表现14子宫腺肌症常见和不常见的MRI表现中英文Atypical Adenomyosis Various physiologic or pathologic states may affect the MR

27、 imaging appearance of adenomyosis:amount of functional endometrial tissue,phase of the menstrual cycle,endogenous hormonal abnormality,and exogenous hormonal stimulation.Secretory transformation of adenomyotic endometrium including stromal decidualizationmay cause a heterogeneous increase in signal

28、 intensity on T2-weighted images.多种生理或病理状态可能会影响子宫腺肌症的MRI表现：功能性子宫内膜组织的量，月经周期的阶段，内源激素的异常，外源激素的刺激。腺肌症子宫内膜的分泌转化包括间质蜕膜化会导致T2WI上信号强度不均质的提高This phenomenon may be encountered during gestation and exogenous progestational therapy or even in patients without specific hormonal stimulation.Congestion or edemato

29、us change may also increase the signal intensity of adenomyosis diffusely or focally on T2-weighted images(Fig 5).这种现象可能发生于怀孕期间，外源性孕激素治疗期间，或者甚至在没有特定激素刺激的患者身上。充血或水肿的变化也可能会在T2WI上弥漫性增加子宫腺肌症的信号强度或者局部信号强度（图5）。15子宫腺肌症常见和不常见的MRI表现中英文In such conditions,MR imaging manifestations may fluctuate,and follow-up M

30、R imaging may be helpful for diagnosis.Gonadotropin-releasing hormone analog is used in the treatment of adenomyosis.After hormonal therapy or menopause,an area of adenomyosis may shrink with decreased signal intensity on T2-weighted images(Fig 6)在这种情况下，MRI表现会变化较大，再一次的复查对诊断有帮助。促性腺激素释放激素类似物被用于治疗子宫腺肌症

31、。激素治疗后或在绝经期时，子宫腺肌症的面积可能会萎缩，并伴随着T2WI上信号强度的降低(图6)。Atypical Adenomyosis 16子宫腺肌症常见和不常见的MRI表现中英文Figure 5.Adenomyosis with focal edema in a 54-year-old woman.(a)Sagittal T2-weighted fast spin-echo MR image shows an enlarged uterus with an ill-defined low-signal-intensity lesion in the posterior myometrium

32、.The low-signal-intensity lesion contains a focal high-signal-intensity masslike area(arrow).(b)On diffusion weighted echo-planar MR image(b=800 sec/mm2),the high-signal-intensity masslike area in a sagittal shows no increase in signal intensity(arrow).a.矢状位T2加权快速自旋回波MR图像显示增大的子宫伴随子宫后壁内界限不清的低信号强度病变。这

33、个低信号病变内包含一个肿块样高信号强度区域（箭头）b.在矢状位扩散加权平面回波MR图像上(b=800 sec/mm2)，这个高信号强度肿瘤样区域没有显示信号强度的增高（箭头）17子宫腺肌症常见和不常见的MRI表现中英文Figure 5.（c）On an image from MR spectroscopy,the high-signal-intensity masslike area shows a low choline peak(Cho)at 3.2 ppm.Biopsy revealed benign adenomyotic tissue with stromal edema.The s

34、ignal intensity of the masslike area is decreased on follow-up T2-weighted images obtained 3 months later.c.在磁共振波谱上，这个高信号强度的肿块样区域在3.2ppm处显示为低的胆碱峰（Cho）。活检发现良性子宫腺肌组织间质水肿，这个肿块样区域的信号强度在3个月后的T2WI图像上降低。MR spectroscopy18子宫腺肌症常见和不常见的MRI表现中英文Figure 6.Adenomyosis in a 50-year-old woman before and after hormon

35、al therapy with gonadotropinre leasing hormone analog.一个50岁女性，子宫腺肌症患者，促性腺激素释放激素类似物治疗前后(a)Axial T2-weighted fast spin-echo MR image shows adenomyosis as an ill-defined heterogeneous low-signal-intensity lesion with linear or reticular high-signal-intensity areas in the anterior myometrium(arrow).(b)A

36、xial T2-weighted fast spin-echo MR image obtained after hormonal therapy shows decreased volume and signal intensity of the area of adenomyosis(arrow).a.在轴位T2加权快速自旋回波MR图像上，子宫腺肌症显示为边界不清的不均匀的低信号强度病变伴随肌层前壁线状或网状高信号强度区域（箭头）b.激素治疗后，获取的轴位T2加权快速自旋回波MR图像显示子宫腺肌症区域的面积和信号强度都下降了19子宫腺肌症常见和不常见的MRI表现中英文In such cond

37、itions,MR imaging manifestations may fluctuate,and follow-up MR imaging may be helpful for diagnosis.Gonadotropin-releasing hormone analog is used in the treatment of adenomyosis.After hormonal therapy or menopause,an area of adenomyosis may shrink with decreased signal intensity on T2-weighted imag

38、es(Fig 6)在这种情况下，MRI表现会变化较大，再一次的复查对诊断有帮助。促性腺激素释放激素类似物被用于治疗子宫腺肌症。激素治疗后或绝经期子宫腺肌症的面积可能会萎缩，并伴随着T2WI上信号强度的降低。Diffusion-weighted imaging with ADC measurement may provide another clue for the diagnosis,because these conditions(secretory transformation,decidualization,congestion or edema)usually increase the

39、 ADC in tissues.A relatively high ADC in adenomyotic lesions with high signal intensity on T2-weighted images may allow differentiation from malignant lesions,which have a low ADC due to their high cellularity(Fig 5)(15).弥散加权成像图像上ADC值的测量可能提供诊断的另一条线索，因为在这些情况下（分泌转化，蜕膜变，充血或水肿）通常会增加组织的ADC值。子宫腺肌症病灶的一个相对高

40、的ADC值和高的T2信号强度可以将其从恶性病变中鉴别出来，因为恶性病变由于其高的细胞密度导致低的ADC值MR spectroscopy may also provide a clue for the diagnosis,because these benign adenomyotic conditions do not show high metabolic activity.A relatively low choline peak in adenomyotic lesions may allow differentiation from malignant tumors,which sho

41、w a high choline peak due to their high metabolic activity(Fig5)磁共振质子波谱也可以提供诊断线索，因为这些良性的腺肌并没有表现为高的代谢活动。子宫腺肌症病变的一个相对低的胆碱峰有助于将其与恶性肿瘤鉴别开，因为恶性肿瘤由于其高的代谢活动显示为高的胆碱峰。Atypical Adenomyosis 20子宫腺肌症常见和不常见的MRI表现中英文The uterine body may show physiologic changes during the menstrual cycle.The low-signal-intensity j

42、unctional zone and adenomyosis are well visualized due to increased signal intensity of the myometrium in the secretory phase(luteal phase).子宫体在月经周期中表现了生理性的变化。由于在分泌期（黄体期）时子宫肌层信号变高，导致能清楚的看到低信号的结合带和子宫腺肌症Decreased signal intensity of the myometrium in the menstrualearly proliferative phase(follicular p

43、hase)may cause widening of the junctional zone,which mimics diffuse adenomyosis.Therefore,MR imaging for the evaluation of a uterine myometrial lesion should be performed in the late proliferativesecretory phase(Fig 7)肌层在月经早期增殖期（卵泡期）信号强度的下降会引起结合带的增宽，使其像弥漫性子宫腺肌症。因此MRI对子宫肌层的评价应该在增生晚期-分泌期进行（图7）Physiolo

44、gic Changes in the Uterine Body during the Menstrual Cycle 在月经周期中子宫体的生理变化22子宫腺肌症常见和不常见的MRI表现中英文Figure 7.Subserosal adenomyosis-like lesion(invasive solid endometriosis)in a 33-year-old woman during different phases of the menstrual cycle.(a)Sagittal T2-weighted fast spin-echo MR image obtained in th

45、e early proliferative phase shows decreased signal intensity of the myometrium.The boundary between the myometrium and a subserosal adenomyosis-like lesion(arrow)is obscure.(b)Sagittal T2-weighted fast spin-echo MR image obtained in the late secretory phase shows increased signal intensity of the my

46、ometrium.The low-signal-intensity junctional zone and the subserosal adenomyosis-likelesion(arrow)are clearly visualized.33岁女性，浆膜下的子宫腺肌样病变，在月经周期的不同阶段a.在增殖早期时相获取的矢状位T2加权快速自旋回波MR图像显示肌层信号强度的下降。肌层和浆膜下子宫腺肌样病变之间的界限是模糊的b.在分泌晚期阶段获得的矢状位T2加权快速自旋回波MR图像显示肌层信号强度增高。低信号强度的结合带和浆膜下腺肌样病变清晰可见23子宫腺肌症常见和不常见的MRI表现中英文Vari

47、ous benign conditions and malignant tumors may mimic adenomyosis:physiologic myometrial contraction,myometrial involvement by pelvic endometriosis,low-grade endometrial stroma sarcoma(LG-ESS),and myometrial metastases 多种良性改变和恶性肿瘤类似于子宫腺肌症：生理肌层收缩，肌层受累的盆腔子宫内膜异位症，低度恶性子宫内膜间质肉瘤（LG-ESS），和肌层转移 Transient myo

48、metrial contraction as a physiologic phenomenon may mimic adenomyosis;this appearance may disappear on subsequent images or at cine MR imaging,whereas focal adenomyosis persists on subsequent images or at cine MR imaging(Fig 8)In the pregnant uterus,myometrium adjacent to the implant site may show l

49、ow signal intensity,which reflects blood supplying a contraction;this finding mimics physiologic contraction or focal adenomyosis(Fig 9).作为一种生理现象的瞬态肌层收缩类似于子宫腺肌症，这种外观可能会消失在随后的图像或电影MRI图像，而局灶性子宫腺肌病持续的存在于随后的图像或电影MR成像。在怀孕的子宫，子宫肌层植入的地方表现为低信号，这反映了血液供给的收缩；这个表现类似于生理性收缩或局灶性腺肌病。Contractions in the pregnant ute

50、rus are commonly seen and usually do not present a diagnostic dilemma;however,radiologists who are not familiar with MR imaging of pregnant women may misdiagnose the contraction 孕妇子宫的收缩很常见，通常不存在诊断的难题，然而，不熟悉怀孕女性MR成像的放射学医生可能会将子宫收缩误诊Benign and Malignant Mimics of Adenomyosis 类似于子宫腺肌症的良性和恶性病变24子宫腺肌症常见和不