大肠癌护理重点课件.ppt

1、Department of Medical Oncology,Jiangsu Province Institute of Cancer Research概述概述 FdUMP:5-氟尿嘧啶脱氧核苷5-单磷酸盐 FdUrd:5-氟尿嘧啶脱氧核苷 MS:蛋氨酸合酶 MTHFR:亚甲基四氢叶酸还原酶 THF:四氢叶酸 TK:胸腺嘧啶脱氧核苷激酶 TP:胸腺啶磷酸化酶 TYMS(TS):胸苷酸合成酶 5,10-CH2-THF:5,10-亚甲基四氢叶酸 5-CH3-THF:5-甲基四氢叶酸 5-FU:5-氟尿嘧啶 DHF:二氢叶酸;DHFR:二氢叶酸还原酶 DHFU:二氢氟尿嘧啶 DPYD:二氢嘧啶脱氢酶

2、 dTMP:脱氧胸苷5-单磷酸盐 dUMP:脱氧尿苷5-单磷酸盐5氟尿嘧啶代谢途径Liver-only metastatic colorectal cancer patients and thymidylate synthase polymorphisms for predicting response to 5-fluorouracil-based chemotherapy。Br J Cancer.2008 Sep 2;99(5):716-21.KaplanMeier survival curves for patients in relation to(a)MTHFR C677T poly

3、morphism(log rank=0.01,p=0.92)and(b)MTHFR A1298C polymorphism(log rank=10.67,p=0.001)KaplanMeier survival curves for patients after 5-FU-based chemotherapy(n=135)in relation to the MTHFR C677T genotypes(log rank=3.86,p=0.05)and MTHFR A1298C genotypes(log rank=6.82,p=0.009)Association of polymorphism

4、s MTHFR C677T and A1298C with risk of colorectal cancer,genetic and epigenetic characteristic of tumors,and response to chemotherapy.Int J Colorectal Dis.2010 Feb;25(2):141-51 MTHFR Gene Polymorphism and Response(79 patients)MTHFR,methylenetetrahydrofolate reductase.&#:P=0.04 Journal of Clinical Oncology,Vol 23,No 7(March 1),2005:pp.1365-1369 Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity:a prospective clinical trial by the German 5-FU Toxicity Study Group J Clin Oncol.2008 May 1;26(13):2131-8