代谢组学进展医学课件.pptx
- 【下载声明】
1. 本站全部试题类文档,若标题没写含答案,则无答案;标题注明含答案的文档,主观题也可能无答案。请谨慎下单,一旦售出,不予退换。
2. 本站全部PPT文档均不含视频和音频,PPT中出现的音频或视频标识(或文字)仅表示流程,实际无音频或视频文件。请谨慎下单,一旦售出,不予退换。
3. 本页资料《代谢组学进展医学课件.pptx》由用户(晟晟文业)主动上传,其收益全归该用户。163文库仅提供信息存储空间,仅对该用户上传内容的表现方式做保护处理,对上传内容本身不做任何修改或编辑。 若此文所含内容侵犯了您的版权或隐私,请立即通知163文库(点击联系客服),我们立即给予删除!
4. 请根据预览情况,自愿下载本文。本站不保证下载资源的准确性、安全性和完整性, 同时也不承担用户因使用这些下载资源对自己和他人造成任何形式的伤害或损失。
5. 本站所有资源如无特殊说明,都需要本地电脑安装OFFICE2007及以上版本和PDF阅读器,压缩文件请下载最新的WinRAR软件解压。
- 配套讲稿:
如PPT文件的首页显示word图标,表示该PPT已包含配套word讲稿。双击word图标可打开word文档。
- 特殊限制:
部分文档作品中含有的国旗、国徽等图片,仅作为作品整体效果示例展示,禁止商用。设计者仅对作品中独创性部分享有著作权。
- 关 键 词:
- 代谢 进展 医学 课件
- 资源描述:
-
1、 11.IntroductionLiver injury due to both prescription and over-the-counter drugs is a growing public health problem.Although drug-induced liver injury(DILI)is a rare cause of acute liver injury in clinical practice,it is the leading cause of acute liver failure(ALF)in the US and most of Europe.处方药和非
2、处方药导致的肝损伤是一个日益严重的公共卫生问题。尽管药物诱导的肝损伤(DILI)在临床实践中是急性肝损伤的罕见原因,但它是美国和大多数欧洲的急性肝衰竭(ALF)的主要原因2.1.IntroductionDespite the extensive safety tests performed in the process of getting a drug to market,DILI remains enigmatic and cannot be predicted in preclinical and clinical trials.Even though different genetic
3、 variants and biomarkers have been associated with the risk of developing DILI,hepatotoxicity remains a very common side effect.尽管在药物上市的过程中进行了广泛的安全性测试,但肝损伤仍然是神秘的,并且不能在临床前和临床试验中预测。不同的遗传变异体和生物标志物与肝损伤发展的风险相关,肝毒性仍然是非常常见的副作用。3.1.IntroductionIn this review we will focus on the potential role ofmetabolomic
4、 study on the diagnosis and prognosis of DILI.在这篇综述中,我们将重点关注代谢组学在肝损伤的诊断和预断中的潜在作用。4.2.The Main Challenges in DILI:Accuracy of Diagnosis and Prediction of EvolutionCurrently,DILI is diagnosed by exclusion of other liver diseases and is frequently misdiagnosed.An important part in the diagnosis of DILI
5、 is to establish a temporal association between a drug and the onset of liver damage.However,in many cases,setting a causal link can be a complex task as most of the idiosyncratic drug-induced reactions occur roughly between a range of 1-2 weeks and 2-3 months from the onset of drug administration 目
6、前,肝损伤是通过排除其他肝病进行诊断的,而且经常被误诊。DILI诊断的一个重要部分是建立药物与肝损伤起始之间的时间关联。然而,在许多情况下,设置因果关联可以说是一件复杂的任务,因为大多数特异性药物诱导的反应大致在给药开始的1-2周和2-3个月的范围内才发生5.2.The Main Challenges in DILI:Accuracy of Diagnosis and Prediction of EvolutionImportantly,our knowledge is scarce not only in terms of diagnostic accuracy.The natural hi
7、story of DILI is still not completely understood重要的是,我们的知识不仅在准确诊断性方面知道的很少。而且 肝损伤的自然史仍然没有完全理解6.2.The Main Challenges in DILI:Accuracy of Diagnosis and Prediction of Evolutionmetabolomics is emerging forcefully in order to identify early toxicity biomarkers from biofluids collected through minimally i
8、nvasive procedures that are specific indicators of liver damage.代谢组学可以通过作为肝损伤的具体指标的微创手术收集生物流体来识别早期毒性的生物标志物。7.3.Metabolomics:Concept and DefinitionMetabolomics offers a view distinct from Genomics and Proteomics.While Genomics and Proteomics tell us what“can happen,”metabolomics tells us what is“real
9、ly happening”and,therefore,is the science that can better characterize the phenotypes of living organisms.代谢组学提供了不同于基因组学和蛋白质组学的一种全新视图。基因组学和蛋白质组学告诉我们“可能发生”,但代谢组学告诉我们“真正发生发生了什么”,因此是更好地表征活性生物体表型的科学8.3.Metabolomics:Concept and DefinitionThe main analytical methods used in metabolomic analyses are nuclea
展开阅读全文