catosal科特壮犬猫疾病支持治疗药物-课件.pptx

1、catosal科特壮犬猫疾病支持治疗药物支持治疗支持治疗是指与特异性疗法配合的附加治疗,它能够缩短犬猫疾病的康复时间！支持治疗支持治疗是指与特异性疗法配合的附加治疗,它能够缩短犬猫疾病的康复时间！支持治疗对犬猫的重要性 一般来说,疾病会降低犬猫新陈代谢机能,而新陈代谢机能降低又会延缓犬猫的康复。临床上特异性治疗可不能恢复患病犬猫的新陈代谢机能。因此促进新陈代谢的支持治疗性药物会明显促进患病宠物的康复。患病犬猫需要额外的能量来帮助疾病康复总结简而言之:患病动物需要更多的能量:a)正常的身体功能需要 b)从疾病中快速康复支持治疗形式 平衡营养 充足休息 注意管理 增加多种维生素和矿物质 保护肝脏等

2、ATP+H2OADP+HPO4ENERGY脂类和糖类最终利用的形式(ATP)ATP 变成ADP并释放细胞利用的能量(如:提供给肌肉细胞)能量的利用方式能量重要的因素整个新陈代谢过程关键因素是磷元素的代谢磷元素在AMP-ADP-ATP循环后,有部分会流失掉理论上,磷元素加入到ADP分子中是提供能量储备的最好方式能量 理想的支持治疗磷会流失,需要不断补充提供含能量储备的磷能帮助细胞更好的工作!随着能量需求的增加,富含能量的磷混合物能够满足新陈代谢的需求CATOSAL就是答案每 ml含量:布他磷 100、00 mgVit B12 0、05 mgMethyl paraben 1、00 mgPhosph

3、orus content:17、3 mg/ml提供磷元素提供维生素其他作用成分磷含量:17、3 mg/mlCatosal 疾病支持治疗的关键科特壮的成分布他磷 有机磷酸无味的白色晶体VB12 ButaphosphaneVitamin B12+The Power of Pink科特壮的成分布他磷 无味的白色晶体作用机理通过促进ADP-ATP循环,促进机体能量 代谢。促进机体的合成代谢过程。激活犬猫机体非特异性免疫反应 恢复疲劳肌肉功能。缓解应激/降低激素水平 De Groot J、,van Der Werf J、,van Reenen C、,Schuurman T、,Schmidt B、(200

4、3):The effect of butafosfan(ponent of Catosal)on psychosocial stress in pigs、J、Vet、Pharmacol、Therap、26(Suppl、1),222-223、Van der Staay J、,De Groot J、,Schmidt B、,Schuurman T、(2006):Effects of Catosal on the physiological and behavioral response to social stress in piglets、Proceedings of the 19th IPVS

5、Congress,Copenhagen,Denmark,Volume 2、Simon F(1990):Study on stress reducing effect of butafosfan in sheep、Institut fr Pharmakologie und Toxikologie,Veterinrmedizinische Universitt,Budapest,Hungary、Bayer ID 12765、Hnsel A、,Fuhrmann H、,Sallmann H、-P,Klee W、(1992):Infusion von Propionate and Butyrat als

6、 Belastungstest zur berprfung mglicher Butafosfanwirkungen auf den Energiestoffwechsel des Rindes、Berl、Mnch、Tierrztl、Wschr、105,361-366、Hasi Su-rong,DU Xiao-yan,ZHU Bei-lei,JIANG Jin-shu(2004a):Studies on Effects of pound Butaphosphan Solution on Endurance Capability and Energy Metabolism in Mice、Act

7、a Veterinaria Et Zootechnica Sinica,35(03),290-294、降低冷热刺激Stress Reduction/control of cortisol increase.Hasi Su-rong et al.(2004a)*:p0.05,*p:0.001 compared to control group*:p0.05 compared to high dose butaphosphan*%High dose butaphosphan(n=15):250 mg/kg butaphosphan once aday for 7 days orally.Low d

8、ose butaphosphan(n=15)125 mg/kg butaphosphan once aday for 7 days orally.Control group(n=15):10 ml/kg physiologic saline once a dayfor 7 days oral.One hour after treatment on the last day,each mouse was placedIn a 300 ml wide-mouthed flask which was sealed with a double layer ofgauze.In order to eva

9、luate the cold tolerance,this was placed in a metabolic cage at 50.5 C with a cyclic pump.But,for the evaluation ofheat tolerance the temperature was 450.5 C.In the cold tolerance study,after 10 hours the number of mice still alivewas recorded.In the heat tolerance study,after 50 minutes,the numbero

10、f mice still alive was recorded、布他磷作用于组织缺氧Hasi Su-rong et al、(2004a)*p:0、05,*p:0、001 pared to control group*存活时间(分钟)High dose butaphosphan(n=12):250 mg/kg butaphosphan once aday for 7 days orally、Low dose butaphosphan(n=12)125 mg/kg butaphosphan once aday for 7 days orally、Control group(n=12):10 ml/

11、kg physiologic saline once a dayfor 7 days oral、One hour after treatment on the last day,each mouse was placedIn a 300 ml wide-mouthed flask which was sealed with transparent glad wrapThat did not admit air and timing was menced、With the termination ofbreathing as the endpoint,the time for each mous

12、e to expire from lack of oxygen was noted,so as to determine the effect of butaphosphanon the tolerance of mice hypoxia、刺激能量产生参考资料:Hasi Su-rong,DU Xiao-yan,ZHU Bei-lei,JIANG Jin-shu(2004a):Studies on Effects of pound Butaphosphan Solution on Endurance Capability and Energy Metabolism in Mice、Acta Ve

13、terinaria Et Zootechnica Sinica,35(03),290-294、HASI Su-rong,JIANG Jin-shu,DU Xiao-yan,ZHU Bei-lei(2005a):Anti-cold stress effects and mechanisms of pound butaphosphan solution、Progress in Veterinary Medicine,26,(03),59-62、HASI Su-rong,JIANG Jin-shu,ZHU Bei-lei,DU Xiao-yan(2005b):Studies on Anti-Heat

14、 Stress Effects and Mechanisms of pound Butafosfan Solution、Acta Veterinaria Et Zootechnica Sinica,36(12),1334-1338、布他磷刺激肝糖元产生Content of liver gycogen(mg/g)*=p0.05,*=p0.001Compared to control groupHasi Su-rong et al.(2004a)Experiment 1(n=12):250 mg/kg butaphosphan once a day for 7 days orally、Experi

15、ment 2(n=12):125 mg/kg butaphosphan once a day for 7 days orally、Control group(n=12):10 ml/kg physiologic saline solution、One hour after last treatment on thelast day,mice were sacrificed andliver glycogen content was determinedvia spectrometer布他磷刺激肌糖元产生Content of muscle glycogen(mg/g)*=p0.01,*=p0.0

16、01Compared to control groupHasi Su-rong et al.(2004a)Experiment 1(n=12):250 mg/kg butaphosphan once a day for 7 days orally、Experiment 2(n=12):125 mg/kg butaphosphan once a day for 7 days orally、Control group(n=12):10 ml/kg physiologic saline solution、One hour after last treatment on thelast day,mic

17、e were sacrificed andmuscle glycogen content was determinedvia spectrometer提高 肌肉中的Tri-phosphate(ATP)含量Content of muscle ATP(mg/g)*=p0.001Compared to control groupHasi Su-rong et al.(2004a)Butaphosphan treatment group(n=12):250 mg/kg butaphosphan once a day for 7 days orally、Control group(n=12):10 ml

18、/kg physiologic saline solution、One hour after last treatment on thelast day,mice were sacrificed andmuscle ATP content was determinedvia HPLC、提高肝脏功能StudiesFrll M、,Witteck Th、,Gengenbach S、,Schmidt B、(2006):Effects of pre-operative application of butaphosphan and cyanocobalamine on reconvalescence c

19、linico-chemical parameters,antioxidavive metabolism and postoperative abomosal emptying in cows with abomosal dislocation、Tierrztl、Prax、34(G):351-356、HASI Su-rong,JIANG Jin-shu,DU Xiao-yan,ZHU Bei-lei(2005a):Anti-cold stress effects and mechanisms of pound butaphosphan solution、Progress in Veterinar

20、y Medicine,26,(03),59-62、HASI Su-rong,JIANG Jin-shu,ZHU Bei-lei,DU Xiao-yan(2005b):Studies on Anti-heat Stress Effects and Mechanisms of pound Butafosfan Solution、Acta Veterinaria Et Zootechnica Sinica,36(12),1334-1338、Sommer H、,Marx D、,und Starker G、(1971):Studies to reduce reproductive disorders i

21、n cattle by using Catosal as metaphylaxis、Dtsch、Tierrtzl、Wschr、78,593 616、Flasshoff F、-H、(1974):Clinical and chemical blood serum investigations in cattle and treatment studies with ornithine-aspartate-product HMV 20 and with Catosal for the reduction of fertility and health disorders、Doctorate Thes

22、is,Tierrztliche Hochschule Hannover,Germany、Marbach W(1980):Alkalische Phosphatase(AP)und Aspartataminotransferase(AST)des Blutplasmas als Parameter der Kondition von Rennpferden und die Wirkung von Coforta/Catosal auf diese Enzyme、Vet、Med、Nahchr、,12、CATOSAL:营养肝脏 ASAT(U/l)50100150200250300350Catosal

23、对照组 谷草转氨酶(ASAT)是一种线粒体内的酶,当肝脏或肌肉损伤或肝脏代谢负担过重是会释放到血液中。科特壮能促进糖异生的过程,如此减轻肝脏的负担。0d1d2d3dpost OP科特壮-药理作用 游离脂肪酸(mol/l)20060010001400180022000d1d2d3dCATOSAL:营养肝脏 血液中的游离脂肪酸含量是脂肪代谢的指标,脂肪代谢不行时其含量高 用科特壮治疗后游离脂肪酸含量比未治疗明显降低Catosal对照组Catosal 药理作用科特壮的成分VB12 水溶性,提供钴元素 需要不断摄入作用方式 调节蛋白质、脂类和碳水化合物的新陈代谢 提供钴元素,帮助红细胞合成。促进蛋氨酸

24、合成,而蛋氨酸是机体蛋白质重要的合成原料。促进身体生长,提高食物利用率。黑色晶体,吸水性科特壮-药理作用CATOSAL:抗氧化作用布他磷是一种-氨基磷酸,能够保护犬猫机体免受氧化损伤。CATOSAL:促进生长发育布他磷能够影响宠物的中间代谢(GIESECKE 1985),主要表现为促进能量代谢、提高蛋白质合成(KAEMMERER 1984,KIETZMANN 1986)和促进生长发育。实验证明,给予科特壮、维生素以及硒元素可使动物生长速度提高38%(El-Sherif et al、,1981)。促进生长发育得益于科特壮能促进新陈代谢和提高肌肉的运动科特壮-药理作用CATOSAL:激活非特异性免

25、疫 科特壮能够阻止因热应激而出现的抗体依赖性细胞毒作用动物试验和细胞学试验均表明,科特壮是一种重要的非特异免疫增强剂CATOSAL:营养肝脏 当血清谷草转氨酶(AST)升高后,应用科特壮能够降低 AST的含量。应激状态下,科特壮能够稳定AST正常水平 Catosal 特别安全布他磷的急性毒性试验特别低 (LD50 鼠/i、v,鸡 i、m、最高为、10,000 mg/kg BW)LD50 口服79、4 ml Catosal/Kg B、W、LD50 皮下 100、0 ml Catosal/Kg B、W、LD50 静脉48、0 ml Catosal/Kg B、W、无致突变,致癌和致畸(三致)作用 对免疫系统没有副作用 布他磷无毒Catosal 用法用量习惯症 促进疾病恢复 增强食欲 感染性疾病辅助治疗:细小病毒感染 冠状病毒感染 犬传染性肝炎原虫感染脓皮症 促进肌肉损伤恢复 Catosal 用法用量其他习惯症 配合肠道寄生虫治疗 缓解应激:变换环境,展示等 身体虚弱 贫血 非生理性脱毛 工作犬、繁殖犬的营养补充剂用法用量犬猫疾病恢复15ml/天0、52、5ml/天增加食欲15ml/天0、52、5ml/天非生理性脱毛4-8天内间隔使用3次,每次0、55ml,用法用量皮下、肌肉和静脉注射均可,鸽子能够口服感谢您的聆听！感谢您的聆听！