禽流感与人类流感病毒课件.ppt

1、禽流感禽流感與人類與人類流感病毒流感病毒Influenza:A Historical PerspectiveOrganism or Infection Total no.of patients N=200(%)Rinovirus 105 (53)Coronavirus 14 (7.0)Influenza 12 (6.0)Parainfluenza 7 (4.0)RSV 4 (2.0)Adenovirus 2 (1.0)Enterovirus 1 (0.5)C.pneumoniae 1 (0.5)M.pneumoniae 1 (0.5)S.pneumoniae 1 (0.5)Double vir

2、us infection 10 (5.0)Viral and bacterial infection 6 (3.0)Etiology of the Common Cold prospective study during 10 months Makela MJ.J Clin Micro 2019流感流感(Influenza)的真面目的真面目Pathogen Total (%)N=267Bacterial pathogens 144 (54)S.pneumonia 129 (48)H.influenza 20 (7)Atypical pathogens 60 (22)C.pnuemoniae 3

3、5 (13)M.pnuemonia 9 (3)Legionella 9 (3)Virus 62 (23)Influenza A 50 (19)Influenza B 2 (1)RSV 11 (4)Community acquired pnuemonia in adults admitted to hospitalLim WS Thorax 2019流行感冒流行感冒流感病毒的分類Influenzae virus:epidemiologyThe Influenza A VirusInfluenza Pandemic:origin?Webster,Robert G.Science.293(5536)

4、:1773,2019Influenza BPredominantInfluenza A PredominantDistribution of Influenza Isolates by SubtypeSeptember 29,2019 June 13,2019A:78%B:22%A:77%B:23%A:49%B:51%A:42%B:58%*A:22%B:78%A:72%B:28%A:41%B:59%A:86%B:14%A:57%B:43%010020030040050060070080040424446485052246810121416182022Influenza AInfluenza B

5、Influenza Viruses Isolated byWHO/NREVSS Collaborating Laboratories2019-0358%A42%B73%A(H1)27%A(H3N2)Influenzae virusSinusitis(鼻竇炎)，Otitis Media(中耳炎)Bronchitis(支氣管炎)，Pneumonia(肺炎)，有下列疾病時會更加重症狀:Asthma(哮喘病)，COPD(慢性阻塞性肺病)流感感染的併發症Systemic ComplicationsMyositis(肌炎),Myocarditis(心肌炎)，Encephalitis(腦炎)胸部併發症胸部併

6、發症Laboratory Diagnosis Transmission of the disease to humans remains a major concernPathogenesisEdematous,cyanotic comb and wattles of a chicken禽流感禽流感Avian Influenza 目前禽流感停留在禽鳥傳染病的階段，偶有目前禽流感停留在禽鳥傳染病的階段，偶有人類因為密切接觸禽鳥，遭大量病毒感染，人類因為密切接觸禽鳥，遭大量病毒感染，但人和人之間不會互相傳染。但人和人之間不會互相傳染。Avian Influenza in Hong Kong 201

7、9:case presentAvian Influenza in Hong Kong 2019:case presentAvian Influenza in Hong Kong 2019 A型流行性感冒型流行性感冒H5N1Avian Influenza in Hong Kong 2019 H9N2 南韓爆發禽流感南韓爆發禽流感(H5N1)上萬雞隻暴斃上萬雞隻暴斃 2019-12-16日本證實自日本證實自1925年以來首度爆發禽流感疫情年以來首度爆發禽流感疫情 2019-1-12 越南禽流感嚴重越南禽流感嚴重 2019-1-15WHO Confirms Fifth Death from Bird Flu in Vietnam 1/18,2019彰化禽流感彰化禽流感 撲殺撲殺2萬蛋雞萬蛋雞 2019/01/16 陳建仁：台灣發生禽流感是必然陳建仁：台灣發生禽流感是必然嘉義縣也傳禽流感嘉義縣也傳禽流感 三萬隻雞下午撲殺三萬隻雞下午撲殺2019-1-17 彰嘉禽流感彰嘉禽流感 疫苗惹的禍疫苗惹的禍2019-01-19WHO警告警告 全球性流感迫在眉睫全球性流感迫在眉睫 2019-1-16 世衛禽流感疫苗研製需時世衛禽流感疫苗研製需時4月月