新型低钠复合离子盐的基础与临床研究-课件.ppt

1、Cardiovascular DiseaseCardiovascular DiseaseCardiovascular Diseaseu脑卒中（脑卒中（54%）缺血性心脏病（）缺血性心脏病（47%）u我国高血压患病率：男性我国高血压患病率：男性20%，女性，女性17%；Cardiovascular DiseaseCardiovascular Disease050100150200250901001101201301400 2.9 5.9 8.7 11.6 14.5Urinary Na(mmol/day)Urinary NaCl(g/day)Systolic Blood Pressure(mmHg

2、)Cardiovascular Diseasel Cardiovascular DiseaseCardiovascular Disease%mg/Kgmg/Kgmg/Kg/65 30 0.8 4 40 25Cardiovascular DiseaseCardiovascular DiseaseCardiovascular DiseaseCardiovascular Disease社区人群研究设计Cardiovascular DiseaseCardiovascular Disease1%Compound ion salt 1%normal salt 8%normal saltRenal glom

3、eruli Cardiac arterioloes Cardiac interstitiumAm J Hypertens 2009;22:934-942 Cardiovascular Disease1%CISalt1%NSalt8%NSalt0510152025Cardiac CollagenVolume Fraction(%)1%CISalt1%NSalt8%NSalt01234Ratio of Perivascular CollagenArea to Luminal Area(Heart)1%CISalt1%NSalt8%NSalt0102030Glomerular CollagenVol

4、ume Fraction(%)1%CISalt1%NSalt8%NSalt05101520Tubular CollagenVolume Fraction(%)1%CISalt1%NSalt8%NSalt01234Glomerular Injury Score1%CISalt1%NSalt8%NSalt01234Tubular Injury Score1%CISalt1%NSalt8%NSalt050100150200250Plasma AngiotensinLevel(pg/mL)1%CISalt1%NSalt8%NSalt0123Renal Cortex AngiotensinLevel(p

5、g/mg)1%CISalt1%NSalt8%NSalt0123Renal Cortex NO Level(mol/L)Am J Hypertens 2009;22:934-942 Cardiovascular Disease人群研究结果24小时尿钠变化Cardiovascular Disease人群研究结果血压的动态变化02461201301401501601700246120130140150160170Compound ion saltNormal salt0246120130140150160170024670809002467080900246708090 Hypertensives

6、Normotensives All participantsMonths after RandomizationBlood Pressure（mmHg）Am J Hypertens 2009;22:934-942 Cardiovascular Disease人群研究结果脉压的动态变化*baselinemonth 2month 4month 601060708090100Normal SaltCompound Ion Salt74.976.474.173.777.773.276.371.6Time after RandomizationPulse Pressure(mmHg)Am J Hypertens 2009;22:934-942 Cardiovascular DiseaseCardiovascular DiseaseCardiovascular DiseaseCardiovascular DiseaseCardiovascular Disease Cardiovascular Disease Cardiovascular DiseaseCardiovascular DiseaseCardiovascular DiseaseCardiovascular Disease