高等教学大一下生物PPT课件:cell-membrane.ppt
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- 高等 教学 大一 生物 PPT 课件 cell membrane
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1、细胞膜(质膜)细胞膜(质膜)Cell membraneunder light microscope:The boundary membrane(separating & communicating)?Think:The features the boundary membrane requiresDramatic differences in chemical composition inside and outside the cell.Substance transportInformation exchangeseparation and communicationThe functio
2、ns of cell membrane?An electron micrograph of a plasma membrane of a human red blood cell- two dark sheets sandwich one bright sheet, 7 nm in width cell membrane(细胞膜)plasma membrane (质膜)Biological membrane(生物膜): plasma membrane(质膜) internal membrane(细胞内膜 ) common structure and similar functions plas
3、ma membrane 3 componentsUnique physicochemical natures and sophisticated interaction1. Membrane lipids2. Membrane proteins 3. Membrane glycoconjugatesNerve myelin: lipid 75Mito membrane: protein 75general: lipid 50 protein 4050、 sugar 110Myelin of the sciatic nerve Inner membrane of the mitochondrio
4、nHistory of discovery1890 ,Overton:root absorption,Found: the more fat-soluble, the easier to be absorbed.The membrane is composed of lipids ?1925,red blood cell extract,Found: the coverage area of lipid molecules is twice as the area of red cell membrane. Lipid bilayer on the membrane?19201930,Foun
5、d: not only lipids!1935,H.Davson & J.Danielli proposed the model for membrane structure,1950 proposed a revision.the membrane structure is a bilayer with proteins bound to the two sides.fluid mosaic model -proposed by Singer & Nicolson in 19701. The lipids are arranged in two closely apposed sheets,
6、 forming a lipid bilayer2. The proteins mosaic in or associated to the lipid bilayer3. The two sides of the membrane is asymmetric4. Both the membrane lipid and membrane proteins are of fluidityFluid mosaic modelAn updated version:glyco-conjugates3. fluidity1. Type and molecular structure2. arrangem
7、ent4. asymmetry(2) cholesterol (2) cholesterol (3) glycolipids(3) glycolipids(1) phospholipids(1) phospholipidsAll are amphipathic- both hydrophilic (water-loving) and hydrophobic (water-fearing)1. Type and molecular structureFigure 11-5 Essential Cell Biology ( Garland Science 2010)Figure 11-6 Esse
8、ntial Cell Biology ( Garland Science 2010)Phospholipid (phosphatidycholine)Polar head(hydrophilic)nonpolar tails(hydrophobic)Figure 11-7 Essential Cell Biology ( Garland Science 2010)Polar head(hydrophilic)nonpolar tails(hydrophobic)Figure 11-8 Essential Cell Biology ( Garland Science 2010)A hydroph
9、ilic molecule attracts water moleculesFigure 11-9 Essential Cell Biology ( Garland Science 2010)A hydrophobic molecule tends to avoid waterFigure 11-10 Essential Cell Biology ( Garland Science 2010)Fat molecules are hydrophobic, whereas phospholipids are amphipathicFigure 11-11a Essential Cell Biolo
10、gy ( Garland Science 2010)Amphipathic molecules - both water-loving and oil-loving2. Arrangement of lipid molecules(1) micelle(2) bilayer(3) liposomeLipid bilayer on the membrane(1) Lateral diffusion(2) rotation(3) flexion(4) flip-flop3. 3. fluidity(1) Phospholipids differ in two halves of bilayer(2
11、) Glycolipids are in the external monolayer of the plasma membrane4. 4. asymmetry of lipid bilayerPhospholipids with a amino acid headGlycolipids and phospholipids with a cholin head2. The structures of membrane proteins1. The ways membrane proteins associate with the lipid bilayer3. The structures
12、versus the functions4. The mobility of membrane proteins1 2 3 4 5 6 7 The ways membrane proteins associate with the lipid bilayerAsymmetry of membrane proteins on the bilayerl Sugars are added at the external surfaces of the bilayerl The cysteines are in the different forms at two sides -free thiols
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