皮肤总论英文ppt课件.pptx
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1、1Schedule of Dermatology&Venereology LectureNo.DateContentsTimeTeacher12-26General consideration(1)2hXinsuo Duan 23-5General consideration(2)2hXinsuo Duan 33-12General consideration(3)2hXinsuo Duan 43-19Viral dermatoses&Bacteria dermatoses 2hShuping Yu 53-26Fungal dermatoses2hShuping Yu 64-2STD(1)sy
2、philis,AIDS2hXinsuo Duan 74-9STD(2)gonorrhea,NGU,CA,chancroid2hXinsuo Duan 84-16Eczema &Dermatitis(1)2hJin Wang 94-23Eczema &Dermatitis(2)2hJin Wang 104-30Drug eruption2hJingliang Wu115-7Urticaria 2hJingliang Wu125-14Papulosquamous diseases2hBaoqiang Li 135-21Bullous Dermatoses2hBaoqiang Li 145-28Cu
3、taneous vasculitis2hBaoqiang Li 156-4Skin appendages2hBaoqiang Li 166-11Vitiligo &Skin tumors2hBaoqiang Li 176-18Practice2h186-25Test2h2Section General Consideration Introduction Structure of Skin Function of Skin Symptom, Sign and Diagnosis of Dermatoses Treatment of Dermatoses3 Introduction The sk
4、in is the largest organ of the body There are more than 2000 kind of skin disease in Dermatology Structure of skin561. Epidermis(structure)71.Epidermis cells keratinocyte melanocyte Langerhans cell Merkel cell8(1) Keratinocyte910Hemi-desmosome11(1) KeratinocyteTransitional phaseVasculature , Muscles
5、 , and Nerves of skinTouch is mediated by Meissner corpuscles and in the dermal papillae, particularly on the palms and soles(3)Apocrine glandsSweat is similar in composition to plasma, containing the same electrolytes, though in a more dilute concentration.Chapter Structure of skinThe skins functio
6、ns includeA significant amount of metabolic wastes and salts is disposed from the sweat.Hair matrixprotein metabolismBaoqiang Liand muscle activity, including shivering(resulting in warmth).Cutaneous mechanisms of temperature control includeMerkel cellMerkel cellThe body interprets external stimuli
7、as heat, cold, pain, light touch, pressure, itch, and even tickleGrowing phasevermilion of the lipSchedule of Dermatology&Venereology Lecturevermilion border of the lip (Fordyces spots)12desmosomehemi-desmosomeDesmosome & Hemi-desmosome13Desmosome14Hemi-desmosome15desmosomehemi-desmosomeDesmosome &
8、Hemi-desmosome16(1) Keratinocyte28d17(2)Melanocytemelanocytepigment-producing cell 1819(2)Melanocyte202122(2)MelanocyteThe vasculature of the dermis is particularly well developed at sites of adnexal structures.Baoqiang Lihemi-desmosomeThey are most abundant on theDistribution of hairthe external au
9、ditory canal (ceruminous glands),Cutaneous vasculitisvermilion of the lipMerkel cellVasculature , Muscles , and Nerves of skinSkin appendages(1) Keratinocyte(4)eccrine glandsIt is composed of a double layer of cuboidal epithelial cells.General consideration(1)Eccrine sweat units are found at virtual
10、ly all skin sites except the vermillion border of the lips, nailbeds, labia minora,glans penis,and inner aspect of the prepuce .protein metabolismPrevent the loss of fluid, electrolyte and nutrient substance.Epidermis(structure)Sweat is secreted by the sweat glands and gives a function of discipatin
11、g heat.23(3) Langerhans cell Langerhans cellantigen presenting cell24(3) Langerhans cellLangerhans cells (CD1a)25(4) Merkel cell Merkel cellcontain intracytoplasmic neurosecretory-like granules, and, through their association with neurites, act as slow adapting touch receptors. 26(4) Merkel cellin t
12、he basal layer of the palms and soles, the oral and genital mucosa, the nail bed, and the follicular infundibula. 272.Dermis collagen fiber reticular fiber elastic fibers base material(ground substance):proteoglycan Cells: Fibroblast mast cell Macrophage dermic arborescent cell Langgerhans cell Pigm
13、entophage Lymphocyte leukocyte282.Dermis collagen fibers29reticular fiber302.Dermis elastic fibersCorrelate with tensity of skin312.Dermisreticulare dermispapillary dermis323. Hypodermis(subcutaneous tissue)HypodermisHypodermis333. Hypodermis(subcutaneous tissue)344. Appendages hair follicle sebaceo
14、us glands eccrine glands apocrine glands nail35(1)Hair and Hair follicleHair:Long hairShort hairWolly hairEpidermisSebaceous glandsHair rootMedullaryHair cuticleCortexInner root sheathOuter root sheathHair matrixHair papilla36Distribution of hair Long hair:scalp, beard, axillae and pubes Short hair
15、:eyebrows, eyelids, nose and auditory meates Smoothness: vermilion of the lip mammary papilla Palm,soles, side of the fingers and toes, nail beds,and certain areas adjacent to mucosal surface,such as the glans penis vellus hair(Wolly hair) : face,neck and trunkAppendageselastic fibersThere are more
16、than 2000 kind of skin disease in DermatologyThe comeum stratum, hair follicle and sebaceous gland are the main path.The deeper, lower horizontal plexus is found at the dermal-subcutaneous interface and is composed of larger blood vessels than those of the superficial plexus.Outer root sheathvermili
17、on of the lipChapter Structure of skin(3)Apocrine glandsCutaneous mechanisms of temperature control includevermilion border of the lip (Fordyces spots)hemi-desmosomedistributionLanggerhans cellapocrine glandsvellus hair(Wolly hair) : face,neck and trunkIt is composed of a double layer of cuboidal ep
18、ithelial cells.Palm,soles, side of the fingers and toes, nail beds,and certain areas adjacent to mucosal surface,such as the glans penisShort hair :eyebrows, eyelids, nose and auditory meatesdermic arborescent cell37Hair growth cycle(speed 0.270.4mm/d,loss70-100/d) anagen3-10yGrowing phase catagen3-
19、4wTransitional phase telogen3mResting phase38Long hair girlLength(10001500mm)= 0.270.4mm/d365d/y10y39(2)Sebaceous glandsIt is composed of lobules of pale-staining cells with abundant lipid in their cytoplasm. 40distributionBe found in greatest abundance on the face and scalp.They are distributed thr
20、oughout all skin sites except the palms and soles. They are always associated with hair follicles except at the following sites: the eyelids (meibomian glands),the buccal mucosa vermilion border of the lip (Fordyces spots)the prepuce (Tysons glands)the female areolas (Montgomerys tubercles). 41(2)se
21、baceous glandsDiseases:Comedopapulepustulecyst 42 It opens into the infundibular portion of the hair follicle. The coiled secretory gland is located at the junction of the dermis and subcutaneous fat. (3)Apocrine glands43(3)Apocrine glandsdecapitation secretion It is composed of a double layer of cu
22、boidal epithelial cells.44Apocrine units of the human body are generally confined to the following sites: axillae, areolae, the anogenital region, the external auditory canal (ceruminous glands), and the eyelids (glands of Moll). The glands do not begin to function until puberty. (3)Apocrine glands4
23、5(4)eccrine glands46(4)eccrine glands cells are of two types: glycogen-rich, large pale cells smaller, darker staining cells The pale glycogen-rich cells form sweatTransitional phaseDistribution of hairOuter root sheathTemperature, pain, and itch sensation are transmitted by unmyelinated nerve fiber
24、s which terminate in the papillary dermis and around hair follicles.Hypodermis(subcutaneous tissue)protein metabolismLanggerhans cellPrevent the loss of fluid, electrolyte and nutrient substance.base material(ground substance):proteoglycanGeneral consideration(1)The pale glycogen-rich cells form swe
25、atEccrine sweat units are found at virtually all skin sites except the vermillion border of the lips, nailbeds, labia minora,glans penis,and inner aspect of the prepuce .the eyelids (meibomian glands),AbsorptionSkin appendages(3)Apocrine glandsvermilion of the lip(4)eccrine glandscarbohydrate and sa
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