绿色简约风帕金森病知识讲解（ppt课件）.pptx

1、远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近帕金森病-关/爱/帕/金/森/患/者疾病预防关爱患者-医学知识培训学习CARE FOR HEALTHPellentesque habitant morbi tristique senectus et netus et malesuada fames ac turpis egestas. Proin pharetra nonummy pede. Mauris et orci.主讲：XXX日期：202X远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近CON

2、TENTS目录01请输入您需要编辑的文本内容流行病学 05请输入您需要编辑的文本内容实验室检查03请输入您需要编辑的文本内容发病机理02请输入您需要编辑的文本内容病因与病理06请输入您需要编辑的文本内容诊断04请输入您需要编辑的文本内容临床表现远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近CARE FOR HEALTH流行病学Parkinsons disease (PD) is a common disorders of nervous functions, mainly affects the elderlyPART ONE远近远近远近远近远

3、近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近是一种常见的中老年神经系统变性疾病流行病学请输入您需要编辑的文本内容01帕金森病（Parkinson disease）又称震颤麻痹（paralysis agitans）远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近黑质多巴胺能神经元变性缺失及路易小体形成。流行病学请输入您需要编辑的文本内容01病理特征：远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近流行病学请输入您需要编辑的文本内容01临床四主征：静止性震颤肌强直运动迟

4、缓姿势步态异常远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近Parkinsons disease (PD) is a common disorders of nervous functions, mainly affects the elderlyCARE FOR HEALTH病因与病理PART TWO远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近病因与病理请输入您需要编辑的文本内容02流行病学年发病率： 85-187/10万50岁以上： 500/10万60岁以上：1000/10万(1%)65岁

5、以上患病率为我国患病人数200万远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近病因与病理请输入您需要编辑的文本内容02病因环境因素2MPTP（1-甲基-4-苯基-1,2,3,6-四氢吡啶） 杀虫剂、除草剂的暴露是危险因素；抽烟和喝咖啡是保护因素遗传因素3-synuclein基因遗传因素决定易感性，特定环境毒物暴露后发病 年龄老化1远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近 病理标志Lewybody 黑质色素变淡 黑质多巴胺神经元减少 病理病因与病理请输入您需要编辑的文本内容02远近远近远近远

6、近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近Parkinsons disease (PD) is a common disorders of nervous functions, mainly affects the elderlyCARE FOR HEALTH发病机理PART THREE远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近发病机理请输入您需要编辑的文本内容03发病机制内外源毒物蛋白质异常沉积氧化应激线粒体功能障碍遗传素质多巴胺神经元凋亡远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近

7、远近远近远近远近远近远近远近远近远近Parkinsons disease (PD) is a common disorders of nervous functions, mainly affects the elderlyCARE FOR HEALTH临床表现PART FOUR远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近多于50岁后发病，男多于女，起病慢，进展缓慢。40岁以前发病者，称为青年性帕金森综合症。N字形进展（一侧上肢同侧下肢 ，对侧上肢对侧下肢）。临床表现请输入您需要编辑的文本内容04临床表现（总体特征）远近远近远近远近远近远近远

8、近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近静止性震颤 肌强直动作迟缓姿势步态异常（Static Tremor）（Rigidity）（Bradykinesia）（Gait Disorder）临床表现请输入您需要编辑的文本内容04临床表现（四主征）远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近临床表现请输入您需要编辑的文本内容041.静止性震颤（ Static Tremor ） 多数患者以震颤为首发症状0146次/秒“搓丸样动作”03 情绪激动时加剧02 多为不对称性03远近远近远近远近远近远近远近远近远近远近远近远近远

9、近远近远近远近远近远近远近远近远近远近远近远近临床表现请输入您需要编辑的文本内容04铅管样强直关节被动运动时，增高的肌张力始终保持一致。齿轮样强直肌张力增高的同时合并由震颤促动肌、拮抗肌张力均增高2.肌强直（Rigidity）远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近是病人最常见和较特殊的表现,可出现小写征、面具脸等临床表现请输入您需要编辑的文本内容043.动作迟缓（Bradykinesia）运动执行困难运动起动困难指病人有：远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近姿势屈曲体势，躯干俯

10、屈，肘关节屈曲，腕关节伸直，髋膝关节略弯曲。步态走路拖步，身体前倾，摆臂减少，慌张步态。临床表现请输入您需要编辑的文本内容044.姿势步态异常（Gait Disorder）远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近便秘出汗皮脂增多小便困难性功能障碍痴呆抑郁睡眠障碍吞咽困难构音障碍临床表现请输入您需要编辑的文本内容04帕金森病的其他表现远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近Parkinsons disease (PD) is a common disorders of nervous

11、functions, mainly affects the elderlyCARE FOR HEALTH实验室检查PART FIVE远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近PET多巴胺转运（DAT）: 18F-FPCIT 、11C-CFT等18F-Dopa多巴胺受体显像脑功能显像经颅超声嗅觉功能检测SPECT99mTc-TRODAT-1，123I-FPCIT等实验室检查请输入您需要编辑的文本内容05有助于PD诊断的客观检测手段远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近Parkinson

12、s disease (PD) is a common disorders of nervous functions, mainly affects the elderlyCARE FOR HEALTH诊断PART SIX远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近四项主征：静止性震颤、 肌强直、动作迟缓 、姿势步态。01左旋多巴治疗有效。02无眼外肌麻痹、小脑体征、锥体系损害等。03诊 断请输入您需要编辑的文本内容06中老年发病，缓慢进行性病程远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近远近感谢观看-关/爱/帕/金/森/患/者疾病预防关爱患者-医学知识培训学习CARE FOR HEALTHPellentesque habitant morbi tristique senectus et netus et malesuada fames ac turpis egestas. Proin pharetra nonummy pede. Mauris et orci.主讲：XXX日期：202X