基础医学北大病理学PPT课件 脑部肿瘤.ppt

1、 Primary intracranial tumor: Glioma 胶质瘤（胶质瘤（40%） Meningioma 脑膜瘤（脑膜瘤（15%） Acoustic neurinoma 听神经瘤（听神经瘤（8%） Metastatic tumors: lung, breast 6 Tumors分类分类发病率发病率children: glioma, medulloblastoma 髓母细胞瘤髓母细胞瘤 Size, location nature Local effect General effect特点特点影响 Biologic histologic malignancy Invasion Met

2、astasistumorDifferentiation分化分化Clinical progressionGenetic changesI. Astrocytoma 星形细胞瘤星形细胞瘤AstrocytomaAnaplastic astrocytoma间变性间变性- -Glioblastoma multiforme多形性胶质母细胞瘤多形性胶质母细胞瘤atypiaatypia, mitotic rate, mitotic rate,capillary, endothelial cells,capillary, endothelial cells,necrosis, hemorrhagenecrosi

3、s, hemorrhageAstrocytomaAnaplastic astrocytomaGlioblastomamultiformepoorly definedgray-whitesolidmultiform 多形性多形性:cyst, necrosis, hemorrhageAstrocytona病变病变P53 mutation / loss of chr. 17pLoss of chr.22qRb mutation / loss of chr.13qP16 deletion / loss of chr.3pLoss of chr.19qLoss of ch.10EGFR gene amp

4、lificationGenetic changes in astrocytomaNormal astrocyteAstrocytomaAnaplastic astrocytomaGlioblaxtomamultiformeGlioblatona multiformemultiformemultiforme 20y Cerebellum Primitive undifferentiated cell small tumor cells, scanty cytoplasm rosette 菊形团菊形团 Seeding through CSF Highly malignantII. Medullob

5、lastoma 髓母细胞瘤髓母细胞瘤 Seeding of medulloblastoma From : arachnoid cell 蛛网膜细胞蛛网膜细胞 部位部位 : arachnoid granulation dura 硬脑膜硬脑膜 大体：大体：solid, gritty 砂粒样砂粒样 光镜：光镜：whorl-like pattern psammoma砂粒体砂粒体 Malignant: rareIII. Meningioma 脑膜瘤脑膜瘤医学课件园 Here is another benign meningioma beneath the dura. These neoplasms are slow growing, but may reach a large size before symptoms lead to detection. From: Schwann cell 大体大体: encapsulated, solitary nerves, spinal roots 光镜光镜: Spindle tumor cells, 排列成排列成 束状，网状束状，网状 BenignIV. Neurilemmoma 神经鞘瘤神经鞘瘤SchwannomaInflammation Tumor Trauma .Edema Hydrocephalus IIPherniation